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Resistance of the stable-towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients.

作者信息

Kloor Matthias

机构信息

Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Clinical Cooperation Unit Applied Tumor Biology, DKFZ (German Cancer Research Center) Heidelberg, Heidelberg, Germany.

出版信息

Ann Transl Med. 2019 Nov;7(21):603. doi: 10.21037/atm.2019.10.29.

DOI:10.21037/atm.2019.10.29
PMID:32047764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7011599/
Abstract
摘要

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本文引用的文献

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ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach.ESMO 关于免疫治疗中肿瘤微卫星不稳定性检测的建议，及其与 PD-1/PD-L1 表达和肿瘤突变负担的关系：基于系统评价的方法。
Ann Oncol. 2019 Aug 1;30(8):1232-1243. doi: 10.1093/annonc/mdz116.
2
Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response.错配修复缺陷肿瘤的遗传多样性影响抗 PD-1 免疫治疗反应。
Science. 2019 May 3;364(6439):485-491. doi: 10.1126/science.aau0447.
3
Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.大多数KRAS突变型和BRAF缺陷型结直肠癌患者可从免疫检查点抑制剂治疗中获得临床益处，且为高度微卫星不稳定。
JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00321. Epub 2019 Mar 4.
4
MSI/MMR-deficient tumor diagnosis: Which standard for screening and for diagnosis? Diagnostic modalities for the colon and other sites: Differences between tumors.微卫星高度不稳定/错配修复缺陷肿瘤诊断：筛查和诊断采用何种标准？结肠及其他部位的诊断方法：肿瘤之间的差异。
Bull Cancer. 2019 Feb;106(2):119-128. doi: 10.1016/j.bulcan.2018.12.008. Epub 2019 Feb 1.
5
Severe necrotizing myositis associated with long term anti-neoplastic efficacy following nivolumab plus ipilimumab combination therapy.纳武利尤单抗联合伊匹单抗治疗后长期抗肿瘤疗效相关的严重坏死性肌炎。
Clin Rheumatol. 2019 Feb;38(2):601-602. doi: 10.1007/s10067-018-4373-y. Epub 2018 Nov 19.
6
Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status.转移性结直肠癌中免疫检查点抑制剂原发性耐药与微卫星不稳定性或错配修复缺陷状态误诊的关联。
JAMA Oncol. 2019 Apr 1;5(4):551-555. doi: 10.1001/jamaoncol.2018.4942.
7
Complex pattern of immune evasion in MSI colorectal cancer.微卫星高度不稳定的结直肠癌中复杂的免疫逃逸模式
Oncoimmunology. 2018 Mar 26;7(7):e1445453. doi: 10.1080/2162402X.2018.1445453. eCollection 2018.
8
Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers.胃肠道癌大患者队列中肿瘤突变负荷、错配修复缺陷和 PD-L1 表达的全景。
Mol Cancer Res. 2018 May;16(5):805-812. doi: 10.1158/1541-7786.MCR-17-0735. Epub 2018 Mar 9.
9
Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.纳武利尤单抗联合伊匹单抗治疗错配修复缺陷/微卫星高度不稳定转移性结直肠癌的持久临床获益。
J Clin Oncol. 2018 Mar 10;36(8):773-779. doi: 10.1200/JCO.2017.76.9901. Epub 2018 Jan 20.
10
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Nat Commun. 2017 Oct 26;8(1):1136. doi: 10.1038/s41467-017-01062-w.