Department of General Internal Medicine, Peking University People's Hospital, Beijing, People's Republic of China.
Lyon Neuroscience Research Center, INSERM U1028-CNRS UMR 5292, School of Medicine, University Claude Bernard, Lyon, France.
Sleep. 2020 Aug 12;43(8). doi: 10.1093/sleep/zsaa018.
To evaluate functional connectivity and topological properties of brain networks, and to investigate the association between brain topological properties and neuropsychiatric behaviors in adolescent narcolepsy.
Resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessment were applied in 26 adolescent narcolepsy patients and 30 healthy controls. fMRI data were analyzed in three ways: group independent component analysis and a graph theoretical method were applied to evaluate topological properties within the whole brain. Lastly, network-based statistics was utilized for group comparisons in region-to-region connectivity. The relationship between topological properties and neuropsychiatric behaviors was analyzed with correlation analyses.
In addition to sleepiness, depressive symptoms and impulsivity were detected in adolescent narcolepsy. In adolescent narcolepsy, functional connectivity was decreased between regions of the limbic system and the default mode network (DMN), and increased in the visual network. Adolescent narcolepsy patients exhibited disrupted small-world network properties. Regional alterations in the caudate nucleus (CAU) and posterior cingulate gyrus were associated with subjective sleepiness and regional alterations in the CAU and inferior occipital gyrus were associated with impulsiveness. Remodeling within the salience network and the DMN was associated with sleepiness, depressive feelings, and impulsive behaviors in narcolepsy.
Alterations in brain connectivity and regional topological properties in narcoleptic adolescents were associated with their sleepiness, depressive feelings, and impulsive behaviors.
评估青少年发作性睡病患者脑网络的功能连接和拓扑属性，并探讨脑拓扑属性与神经精神行为之间的关系。
对 26 例青少年发作性睡病患者和 30 例健康对照者进行静息态功能磁共振成像（fMRI）和神经心理学评估。fMRI 数据采用三种方法进行分析：组独立成分分析和图论方法用于评估全脑的拓扑属性。最后，采用基于网络的统计方法进行组间区域间连接比较。采用相关分析探讨拓扑属性与神经精神行为的关系。
除了嗜睡外，还发现青少年发作性睡病患者存在抑郁症状和冲动。在青少年发作性睡病中，边缘系统和默认模式网络（DMN）之间的功能连接减弱，而视觉网络的功能连接增强。青少年发作性睡病患者的小世界网络属性受损。尾状核（CAU）和后扣带回的区域改变与主观嗜睡有关，而 CAU 和枕下回的区域改变与冲动有关。杏仁核和 DMN 内的重塑与嗜睡、抑郁感和发作性睡病患者的冲动行为有关。
青少年发作性睡病患者脑连接和区域拓扑属性的改变与他们的嗜睡、抑郁感和冲动行为有关。
