Thieux Marine, Lioret Julien, Bouet Romain, Guyon Aurore, Lachaux Jean-Philippe, Herbillon Vania, Franco Patricia
Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, 69500 Lyon, France.
Unité de Sommeil Pédiatrique, Service d'épileptologie Clinique, des Troubles du Sommeil et de Neurologie Fonctionnelle de l'enfant, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, 69500 Lyon, France.
J Clin Med. 2024 Aug 27;13(17):5077. doi: 10.3390/jcm13175077.
No device is yet available to effectively capture the attentional repercussions of hypersomnolence (HYP). The present study aimed to compare attentional performance of children with HYP, attention deficit hyperactivity disorder (ADHD), and controls using behavioral and electrophysiological (EEG) markers, and to assess their relationship with conventional sleepiness measurements. Children with HYP underwent a multiple sleep latency test (MSLT) and completed the adapted Epworth sleepiness scale (AESS). Along with age-matched children with ADHD, they were submitted to a resting EEG followed by the Bron-Lyon Attention Stability Test (BLAST). The control group only performed the BLAST. Multivariate models compared reaction time (RT), error percentage, BLAST-Intensity, BLAST-Stability, theta activity, and theta/beta ratio between groups. Correlations between these measures and conventional sleepiness measurements were conducted in children with HYP. . Children with HYP had lower RT and BLAST-Stability than controls but showed no significant difference in BLAST/EEG markers compared to children with ADHD. The AESS was positively correlated with the percentage of errors and negatively with BLAST-Intensity. . Children with HYP showed impulsivity and attention fluctuations, without difference from children with ADHD for BLAST/EEG markers. The BLAST-EEG protocol could be relevant for the objective assessment of attentional fluctuations related to hypersomnolence.
目前还没有能够有效捕捉嗜睡症（HYP）对注意力影响的设备。本研究旨在使用行为和电生理（脑电图，EEG）指标比较患有嗜睡症、注意力缺陷多动障碍（ADHD）的儿童以及对照组儿童的注意力表现，并评估它们与传统嗜睡测量方法之间的关系。患有嗜睡症的儿童接受了多次睡眠潜伏期测试（MSLT）并完成了改编后的爱泼华嗜睡量表（AESS）。他们与年龄匹配的患有ADHD的儿童一起接受静息脑电图检查，随后进行布朗-里昂注意力稳定性测试（BLAST）。对照组仅进行BLAST测试。多变量模型比较了各组之间的反应时间（RT）、错误百分比、BLAST强度、BLAST稳定性、θ波活动以及θ/β比值。对患有嗜睡症的儿童进行了这些测量指标与传统嗜睡测量方法之间的相关性分析。患有嗜睡症的儿童的RT和BLAST稳定性低于对照组，但与患有ADHD的儿童相比，在BLAST/EEG指标上没有显著差异。AESS与错误百分比呈正相关，与BLAST强度呈负相关。患有嗜睡症的儿童表现出冲动性和注意力波动，在BLAST/EEG指标上与患有ADHD的儿童没有差异。BLAST-EEG方案可能与客观评估与嗜睡症相关的注意力波动有关。
