University Clinics of Bonn, BMZ, Institute of Pharmacology and Toxicology, Venusberg-Campus 1, 53127, Bonn, Germany.
Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15089, Białystok, Poland.
Pharmacol Rep. 2020 Apr;72(2):271-284. doi: 10.1007/s43440-019-00047-4. Epub 2020 Jan 20.
About 40% of the papers within the scientific oeuvre of Manfred Göthert (1939-2019) were dedicated to serotonin (5-hydroxytryptamine, 5-HT). He was not only the witness of the gradual definition of the fourteen 5-HT receptor subtypes but also was involved directly by identifying 5-HT, 5-HT and 5-HT receptors. Moreover, he identified presynaptic 5-HT receptors on central and/or peripheral serotoninergic, noradrenergic and/or cholinergic neurones. Two inhibitory (5-HT, 5-HT) and two facilitatory (5-HT, 5-HT) receptors were found, the 5-HT receptor representing a possible target for antidepressant drugs. Ten years earlier than electrophysiologists, he identified ligand-gated receptors like the 5-HT and the nicotinic acetylcholine (nACh) receptor as targets of halothane. Simultaneously with, but independent of, other authors he found that ethanol allosterically inhibits N-methyl-D-aspartate (NMDA) receptors, which are affected at an even lower concentration than 5-HT and nACh receptors. The latter two receptors were shown to be subject to allosteric inhibition also by cannabinoids via a mechanism unrelated to cannabinoid CB or CB receptors; cannabinoid inhibition of 5-HT receptors may represent a new target for the treatment of neuropathic pain.
曼弗雷德·戈特特（Manfred Göthert，1939-2019）的科学著作中约有 40%是关于血清素（5-羟色胺，5-HT）的。他不仅见证了 14 种 5-HT 受体亚型的逐步定义，还直接参与了 5-HT、5-HT 和 5-HT 受体的鉴定。此外，他还鉴定了中枢和/或外周 5-羟色胺能、去甲肾上腺素能和/或胆碱能神经元上的突触前 5-HT 受体。发现了两种抑制性（5-HT、5-HT）和两种易化性（5-HT、5-HT）受体，5-HT 受体可能成为抗抑郁药物的靶点。比电生理学家早十年，他鉴定了配体门控受体，如 5-HT 和烟碱型乙酰胆碱（nACh）受体，它们是氟烷的作用靶点。他与其他作者同时但独立地发现，乙醇通过变构抑制 N-甲基-D-天冬氨酸（NMDA）受体，其受影响的浓度甚至低于 5-HT 和 nACh 受体。后来发现，大麻素通过与大麻素 CB 或 CB 受体无关的机制，也能变构抑制这两种受体；大麻素抑制 5-HT 受体可能成为治疗神经性疼痛的新靶点。
