通过对醌甲醚构建三氟甲基化的季立体中心。
Construction of trifluoromethylated quaternary stereocenters via p-quinone methides.
机构信息
Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei 184-8588, Japan.
Department of Biomolecular Functional Engineering, Ibaraki University, Nakanarusawa 4-12-1, Hitachi 316-8511, Japan.
出版信息
Chem Commun (Camb). 2020 Mar 10;56(20):3031-3034. doi: 10.1039/c9cc08936e.
Development of a new synthetic method for the construction of quaternary centers with a trifluoromethyl group was realized by way of 1,6-addition of various nucleophiles including active methylene compounds to highly reactive δ-trifluoromethylated p-quinone methides generated in situ from the corresponding tertiary carbonates with a catalytic amount of an appropriate base.
通过催化量的适当碱与相应叔碳酸酯原位生成的高反应性 δ-三氟甲基化 p-醌亚甲基化合物的 1,6-加成，实现了具有三氟甲基的季碳原子的新合成方法的发展，该加成包括各种亲核试剂，包括活泼亚甲基化合物。
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