通过由生成的CF-醌甲基化物和硫叶立德进行[4+1]环化反应实现CF-二氢苯并呋喃的非对映选择性合成。
Diastereoselective synthesis of CF-dihydrobenzofurans by [4+1] annulation of -generated CF--quinone methides and sulfur ylides.
作者信息
Jha Babli K, Prudhviraj Jaggaraju, Mainkar Prathama S, Punna Nagender, Chandrasekhar Srivari
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology Hyderabad 500007 India
Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India.
出版信息
RSC Adv. 2020 Oct 20;10(63):38588-38591. doi: 10.1039/d0ra08289a. eCollection 2020 Oct 15.
An efficient and highly diastereoselective synthesis of CF-dihydrobenzofurans by the reaction of -generated CF-QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF-QM has been utilized first time for the annulation reaction.
提出了一种在碱存在下，通过生成的CF-QMs与硫叶立德反应高效且高非对映选择性地合成CF-二氢苯并呋喃的方法。用多种底物对本开发方法的通用性进行了深入研究，以优异的产率获得相应产物。高反应活性的CF-QM首次用于环化反应。
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