Department of Ultrasound, Peking University Third Hospital, Beijing, China.
Ordos Center Hospital, Ordos 017000, Inner Mongolia, China.
Curr Med Chem. 2021;28(3):525-547. doi: 10.2174/0929867327666200212100257.
Ultrasound has been broadly used in biomedicine for both tumor diagnosis as well as therapy. The applications of recent developments in micro/nanotechnology promote the development of ultrasound-based biomedicine, especially in the field of ultrasound-based drug delivery and tumor therapy. Ultrasound can activate nano-sized drug delivery systems by different mechanisms for ultrasound- triggered on-demand drug release targeted only at the tumor sites. Ultrasound Targeted Microbubble Destruction (UTMD) technology can not only increase the permeability of vasculature and cell membrane via sonoporation effect but also achieve in situ conversion of microbubbles into nanoparticles to promote cellular uptake and therapeutic efficacy. Furthermore, High Intensity Focused Ultrasound (HIFU), or Sonodynamic Therapy (SDT), is considered to be one of the most promising and representative non-invasive treatment for cancer. However, their application in the treatment process is still limited due to their critical treatment efficiency issues. Fortunately, recently developed micro/nanotechnology offer an opportunity to solve these problems, thus improving the therapeutic effect of cancer. This review summarizes and discusses the recent developments in the design of micro- and nano- materials for ultrasound-based biomedicine applications.
超声在肿瘤诊断和治疗中都得到了广泛的应用。微纳技术的最新发展促进了超声为基础的生物医学的发展，特别是在超声为基础的药物输送和肿瘤治疗领域。超声可以通过不同的机制激活纳米级药物输送系统，实现超声触发的按需药物释放，靶向仅在肿瘤部位。超声靶向微泡破坏（UTMD）技术不仅可以通过声孔效应增加血管和细胞膜的通透性，还可以将微泡原位转化为纳米颗粒，促进细胞摄取和治疗效果。此外，高强度聚焦超声（HIFU）或声动力学治疗（SDT）被认为是最有前途和代表性的癌症非侵入性治疗方法之一。然而，由于其关键的治疗效率问题，它们在治疗过程中的应用仍然受到限制。幸运的是，最近发展的微纳技术提供了一个解决这些问题的机会，从而提高了癌症的治疗效果。本综述总结和讨论了用于超声为基础的生物医学应用的微纳材料设计的最新进展。
