TIGAR 对活性氧的动态调控：平衡抗癌和促转移效应。
Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects.
机构信息
Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Cancer Cell. 2020 Feb 10;37(2):141-142. doi: 10.1016/j.ccell.2020.01.009.
The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TIGAR expression.
活性氧（ROS）在癌症中的作用复杂，研究表明其具有促进肿瘤和抑制肿瘤的双重效应。在胰腺导管腺癌模型中，通过 TIGAR 限制 ROS 最初支持癌症发展，但后来在转移细胞中成为代谢负担，通过降低 TIGAR 表达来抵消。
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