Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Cancer Cell. 2020 Feb 10;37(2):143-144. doi: 10.1016/j.ccell.2020.01.006.
CAR T cells with different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have different kinetics of activation, antigen sensitivity, and susceptibility to exhaustion. Two recent studies identified that these functions are shaped by a balance among opposing signaling complexes and transcription factors competing for binding motifs.
嵌合抗原受体 T 细胞（CAR T 细胞）带有不同的共刺激结构域，已被证明在白血病和淋巴瘤中有临床疗效，但它们的激活动力学、抗原敏感性和对衰竭的易感性不同。最近的两项研究表明，这些功能是由相互竞争结合基序的拮抗信号复合物和转录因子之间的平衡所塑造的。
