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新生儿期开始治疗的先天性甲状腺功能减退症女孩的运动、交流和认知技能表现。

Performance in motor, communicative and cognitive skills of girls with congenital hypothyroidism treated from the neonatal period.

作者信息

Lamônica Dionísia Aparecida Cusin, Anastácio-Pessan Fernanda da Luz, Ferraz Plínio Marcos Duarte Pinto, Ribeiro Camila da Costa

机构信息

Faculdade de Odontologia de Bauru - Bauru (SP), Brasil.

Clínica Neuroped - Bauru (SP), Brasil.

出版信息

Codas. 2020 Feb 10;32(1):e20190017. doi: 10.1590/2317-1782/20192019017. eCollection 2020.

Abstract

OBJECTIVE

To compare the performance in gross motor, fine motor-adaptive, language, cognitive and personal-social development skills of girls with a mean age of 36 to 71 months with Congenital Hypothyroidism treated from the neonatal period with that of their peers without thyroid alterations.

METHODS

The participants included in the study were 30 children aged between 36 and 70 months divided into two groups paired for chronological age and socioeconomic status: 15 girls diagnosed with Congenital Hypothyroidism - Experimental Group (EG) and 15 girls without thyroid changes - Control Group (CG). The following assessment instruments were used: Interview with parents, Peabody Picture Vocabulary Test - Revised (PPVT-R), and Denver Developmental Screening Test - 2nd edition (DDST-II). Psychological testing of intellectual functioning was conducted with application of the Stanford-Binet Intelligence Scale (SBIS). The descriptive statistical analysis was performed using Student's t-test and the Mann-Whitney test at a significance level of 5% (p<0.05).

RESULTS

Comparison of the PPVT-R and SBIS results showed a statistically significant difference between the EG and CG. Comparison of the DDST-II results showed a statistically significant difference between the groups for the fine motor-adaptive, language and gross motor areas.

CONCLUSION

The present study confirms that Congenital Hypothyroidism affects child development, even when children are diagnosed and treated early, leading to alterations that can impair their motor, cognitive and language development.

摘要

目的

比较平均年龄在36至71个月的先天性甲状腺功能减退症女童自新生儿期开始接受治疗后的粗大运动、精细运动-适应性、语言、认知及个人-社会发展技能表现与无甲状腺改变的同龄女童的表现。

方法

本研究纳入的参与者为30名年龄在36至70个月之间的儿童,根据实际年龄和社会经济地位分为两组:15名被诊断为先天性甲状腺功能减退症的女童——实验组(EG)和15名无甲状腺改变的女童——对照组(CG)。使用了以下评估工具:家长访谈、修订版皮博迪图片词汇测试(PPVT-R)和丹佛发育筛查测试第二版(DDST-II)。应用斯坦福-比奈智力量表(SBIS)对智力功能进行心理测试。采用学生t检验和曼-惠特尼检验进行描述性统计分析,显著性水平为5%(p<0.05)。

结果

PPVT-R和SBIS结果的比较显示,实验组和对照组之间存在统计学显著差异。DDST-II结果的比较显示,两组在精细运动-适应性、语言和粗大运动领域存在统计学显著差异。

结论

本研究证实,先天性甲状腺功能减退症会影响儿童发育,即使儿童早期被诊断并接受治疗,也会导致可能损害其运动、认知和语言发育的改变。

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