Campos Felipe Alverenga Duarte, Ritt Luiz Eduardo Fonteles, Costa João Paulo Soares, Cruz Constança Margarida, Feitosa-Filho Gilson Soares, Oliveira Queila Borges de, Darzé Eduardo Sahade
Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brazil.
Hospital Cárdio Pulmonar,Salvador, BA - Brazil.
Arq Bras Cardiol. 2020 Mar;114(3):477-483. doi: 10.36660/abc.20180377.
Takotsubo syndrome (TTS) is characterized by a temporary systolic dysfunction of the left ventricle (LV) related to a stressful event. However, the factors associated with its recurrence are still not well established.
To analyze the main factors associated with TTS recurrence.
A systematic review was performed using the PRISMA model. Observational studies, published between January 2008 and October 2017, which presented a recurrence rate of at least 3% and/or 5 or more patients with recurrence, and who met at least 80% of the STROBE criteria were included.
six articles reached the criteria to compose this systematic review. The recurrence rate ranged from 1 to 3.5% per year (global recurrence rate 3.8%). One study associated higher recurrence rate with the female gender, four reported the time between the first and second episodes, one study associated body mass index (BMI) and hypercontractility of the LV middle anterior wall to a higher recurrence rate. No association between recurrence and electrocardiographic changes were determined. Beta-blockers use was not associated with recurrence rates.
Female gender, time from the first episode of the syndrome, low BMI and midventricular obstruction were reported as potential predictors of TTS recurrence.
应激性心肌病（TTS）的特征是与应激事件相关的左心室（LV）暂时性收缩功能障碍。然而，与其复发相关的因素仍未完全明确。
分析与TTS复发相关的主要因素。
采用PRISMA模型进行系统评价。纳入2008年1月至2017年10月发表的观察性研究，这些研究的复发率至少为3%和/或有5例或更多复发患者，且至少符合80%的STROBE标准。
6篇文章符合纳入本系统评价的标准。复发率为每年1%至3.5%（总体复发率3.8%）。一项研究发现女性复发率较高，4项研究报告了首次发作与第二次发作之间的时间间隔，一项研究发现体重指数（BMI）和左心室中前壁的高收缩性与较高的复发率相关。未确定复发与心电图变化之间的关联。使用β受体阻滞剂与复发率无关。
女性、首次发作后的时间、低BMI和心室中部梗阻被报告为TTS复发的潜在预测因素。
