College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China.
Changsha Qiangze Biotech Co., Ltd., Changsha, China.
Bioinformatics. 2020 May 1;36(10):3251-3253. doi: 10.1093/bioinformatics/btaa083.
Newly emerging influenza viruses keep challenging global public health. To evaluate the potential risk of the viruses, it is critical to rapidly determine the phenotypes of the viruses, including the antigenicity, host, virulence and drug resistance.
Here, we built FluPhenotype, a one-stop platform to rapidly determinate the phenotypes of the influenza A viruses. The input of FluPhenotype is the complete or partial genomic/protein sequences of the influenza A viruses. The output presents five types of information about the viruses: (i) sequence annotation including the gene and protein names as well as the open reading frames, (ii) potential hosts and human-adaptation-associated amino acid markers, (iii) antigenic and genetic relationships with the vaccine strains of different HA subtypes, (iv) mammalian virulence-related amino acid markers and (v) drug resistance-related amino acid markers. FluPhenotype will be a useful bioinformatic tool for surveillance and early warnings of the newly emerging influenza A viruses.
It is publicly available from: http://www.computationalbiology.cn : 18888/IVEW.
Supplementary data are available at Bioinformatics online.
新出现的流感病毒不断挑战着全球公共卫生。为了评估这些病毒的潜在风险，快速确定病毒的表型（包括抗原性、宿主、毒力和耐药性）至关重要。
在这里，我们构建了 FluPhenotype，这是一个一站式平台，可以快速确定甲型流感病毒的表型。FluPhenotype 的输入是完整或部分甲型流感病毒的基因组/蛋白质序列。输出提供了有关病毒的五类信息：（i）序列注释，包括基因和蛋白质名称以及开放阅读框，（ii）潜在宿主和与人适应相关的氨基酸标记，（iii）与不同 HA 亚型疫苗株的抗原和遗传关系，（iv）哺乳动物毒力相关的氨基酸标记和（v）耐药性相关的氨基酸标记。FluPhenotype 将成为监测和预警新出现的甲型流感病毒的有用生物信息学工具。
它可通过以下网址公开获取：http://www.computationalbiology.cn:18888/IVEW。
补充数据可在生物信息学在线获取。
