CHRNA5 rs16969968 多态性与肺癌风险相关：一项荟萃分析。

CHRNA5 rs16969968 polymorphism is associated with lung cancer risk: A meta-analysis.

机构信息

Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Beijing, China.

Department of Integrative Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Clin Respir J. 2020 Jun;14(6):505-513. doi: 10.1111/crj.13165. Epub 2020 Mar 3.

DOI:10.1111/crj.13165

PMID:32049419

Abstract

OBJECTIVE

To evaluate the genetic association between rs16969968 and lung cancer risk by meta-analysis.

DATA SOURCE

We searched eligible studies from MEDLINE, Web of Science and EMBASE up to Dec, 2017.

STUDY SELECTION

Association studies concerning rs16969968 and lung cancer risk were included. We assessed the association strength between this polymorphism and risk of lung cancer by calculating odds ratios (OR) and 95% confidence interval (95%CI).

RESULTS

A total of 26 data sets comprising 30 772 lung cancers and 90 954 controls were included. rs16969968 was found to be associated with lung cancer risk in population of European ancestry in all models (A vs. G: OR = 1.30, 95%CI 1.27-1.33, P < 0.001; AA + GA vs. GG: OR = 1.38, 95%CI 1.33-1.43, P < 0.001; AA vs. GG + GA: OR = 1.45, 95%CI 1.38-1.53, P < 0.001), consistent with previous genome-wide association study (GWAS). However, no association was observed in Asians (A vs. G: OR = 1.19. 95%CI 0.95-1.49, P = 0.131). The minor allele A may increase the risk of lung cancer in both smokers (OR = 1.33, 95%CI 1.29-1.39, P < 0.001) and nonsmokers (OR = 1.25, 95%CI 1.12-1.39, P < 0.001). There was no obvious publication bias in all analyses.

CONCLUSIONS

Our analysis provided more evidence that rs16969968 is a susceptibility locus of lung cancer in the Caucasians and that it may be not associated with the risk in the Asians.

摘要

目的

通过荟萃分析评估 rs16969968 与肺癌风险的遗传关联。

数据来源

我们检索了 MEDLINE、Web of Science 和 EMBASE 中截至 2017 年 12 月的合格研究。

研究选择

纳入了 rs16969968 与肺癌风险相关的关联研究。我们通过计算比值比（OR）和 95%置信区间（95%CI）来评估该多态性与肺癌风险之间的关联强度。

结果

共纳入 26 项数据，包括 30772 例肺癌和 90954 例对照。在所有模型中，rs16969968 与欧洲裔人群的肺癌风险相关（A 与 G：OR=1.30，95%CI 1.27-1.33，P<0.001；AA+GA 与 GG：OR=1.38，95%CI 1.33-1.43，P<0.001；AA 与 GG+GA：OR=1.45，95%CI 1.38-1.53，P<0.001），与之前的全基因组关联研究（GWAS）一致。然而，在亚洲人群中未观察到相关性（A 与 G：OR=1.19，95%CI 0.95-1.49，P=0.131）。次要等位基因 A 可能会增加吸烟者（OR=1.33，95%CI 1.29-1.39，P<0.001）和非吸烟者（OR=1.25，95%CI 1.12-1.39，P<0.001）患肺癌的风险。在所有分析中均未发现明显的发表偏倚。