Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585 Singapore.
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
ACS Nano. 2020 Mar 24;14(3):3259-3271. doi: 10.1021/acsnano.9b08798. Epub 2020 Feb 21.
The cancer cell membrane contains an arsenal of highly specific homotypic moieties that can be used to recognize its own kind. These cell membranes are often used to coat spherical nanoparticles to enhance nanomedicines' targeting specificities and uptakes. A sphere, however, has only a point contact with a surface at any given time. It is shown here that, by retaining a flatter morphology of the cracked cell membrane through stiffening with synthesized gold nanomaterials, an increased area of interaction could be maintained and hence improve upon the and homotypic targeting capabilities between cancer cell types. This enhancement is especially important as any nanomedicine with targeting moieties probably has a single pass at interacting with the target cell before subsequent system clearance. Possible future clinical applications may involve the usage of a patient's autologous tumor biopsy tissues, which are very limited in supply, and therefore ensuring that we capitalize on the entire collective surface area of the cancer cell membrane available becomes an important consideration in the design and delivery our cell membrane-derived nanomedicines.
癌细胞膜包含一系列高度特异性的同种型部分，可用于识别自身类型。这些细胞膜常用于涂覆球形纳米粒子，以增强纳米药物的靶向特异性和摄取。然而，球体在任何给定时间都只有一个点与表面接触。这里显示的是，通过用合成的金纳米材料使破裂的细胞膜保持更平坦的形态，增加了相互作用的面积，从而提高了同种型靶向癌症细胞类型的能力。这种增强尤其重要，因为任何具有靶向部分的纳米药物在随后的系统清除之前可能只有一次与靶细胞相互作用的机会。未来可能的临床应用可能涉及使用患者自身的肿瘤活检组织，而这些组织的供应非常有限，因此确保我们充分利用可用的癌细胞膜的整个集体表面积成为设计和输送我们的细胞膜衍生纳米药物的重要考虑因素。
