Liu Minghui, Niu Jun-Long, Yang Dandan, Song Mao-Ping
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
J Org Chem. 2020 Mar 20;85(6):4067-4078. doi: 10.1021/acs.joc.9b03073. Epub 2020 Feb 26.
A new traceless directing group, 2-(hydroxymethyl)pyridine, has been reported for the Cp*-free cobalt-catalyzed C-H activation/annulation reaction to synthesize isoquinolinones. The reaction exhibits good functional group tolerance, affording products in good to excellent isolated yields under mild conditions. Notably, the directing group can be removed directly in situ along the catalytic process.
据报道，一种新型无痕导向基团2-(羟甲基)吡啶可用于无Cp*钴催化的C-H活化/环化反应以合成异喹啉酮。该反应具有良好的官能团耐受性，在温和条件下能以良好至优异的分离产率得到产物。值得注意的是，导向基团可在催化过程中原位直接除去。
