Department of Orthopaedic Surgery, Southern California Permanente Medical Group, San Diego, California, USA.
Surgical Outcomes and Analysis, Kaiser Permanente, San Diego, California, USA.
Am J Sports Med. 2020 Mar;48(4):806-811. doi: 10.1177/0363546520902716. Epub 2020 Feb 12.
Hamstring autograft anterior cruciate ligament reconstructions (ACLRs) have exhibited higher infection rates compared with bone-patellar tendon-bone (BPTB) autograft. The reason for this observed difference is unclear, warranting investigation.
To evaluate the association between tibial fixation, either with or without a sheath and screw construct, and the risk of deep infection after hamstring autograft ACLR, using BPTB autograft as a reference group for comparison.
Cohort study; Level of evidence, 3.
Using the Kaiser Permanente ACLR Registry, we identified all primary isolated, unilateral, single-bundle ACLRs with a BPTB or hamstring autograft (January 1, 2008, to September 30, 2016). The exposure groups included the following: (1) BPTB ACLR, (2) hamstring ACLR using a screw and sheath construct for tibial fixation (HS with screw and sheath), and (3) hamstring ACLR using a method other than a screw and sheath construct for tibial fixation (HS without screw and sheath). We used logistic regression to evaluate the likelihood of 90-day postoperative deep infection using BPTB autograft as the reference group and adjusting for age, sex, and body mass index. The number needed to be exposed (NNE) was calculated.
Of 15,671 ACLRs, 6745 (43.0%) used a BPTB graft, 2852 (18.2%) used HS with screw and sheath tibial fixation, and 6074 (38.8%) used HS without screw and sheath tibial fixation. There were 38 (0.2%) 90-day deep infections: 11 (0.2%) for BPTB, 14 (0.5%) for HS with screw and sheath, and 13 (0.2%) for HS without screw and sheath. for the BPTB group and in both hamstring groups were the most common infecting organisms. HS with screw and sheath had a higher likelihood of 90-day deep infection compared with BPTB ACLR (odds ratio [OR], 2.87; 95% CI, 1.29-6.38). We failed to observe a difference for HS without screw and sheath compared with BPTB ACLR (OR, 1.23; 95% CI, 0.54-2.77). The NNE was 330 and 2701 for HS with and HS without screw and sheath, respectively.
Although the overall infection rate after ACLR is low, the higher likelihood of infections when sheath and screw combined are used for tibial fixation of a hamstring autograft ACLR should be a consideration when this procedure is performed.
相比于骨-髌腱-骨(BPTB)自体移植物,腘绳肌腱自体前交叉韧带重建(ACLR)的感染率更高。造成这种观察到的差异的原因尚不清楚,值得进一步研究。
使用 BPTB 自体移植物作为参照组进行比较,评估胫骨固定时是否使用套管和螺钉结构,以及使用套管和螺钉结构(HS 带套管和螺钉)或不使用套管和螺钉结构(HS 不带套管和螺钉)对腘绳肌腱 ACLR 后深部感染的风险的影响。
队列研究;证据等级,3 级。
使用 Kaiser Permanente ACLR 注册中心,我们确定了所有 2008 年 1 月 1 日至 2016 年 9 月 30 日期间接受初次、单侧、单束 ACLR 的患者,包括 BPTB 或腘绳肌腱自体移植物(15671 例)。暴露组包括:(1)BPTB ACLR;(2)胫骨固定时使用螺钉和套管结构的腘绳肌腱 ACLR(HS 带螺钉和套管);(3)胫骨固定时不使用螺钉和套管结构的腘绳肌腱 ACLR(HS 不带螺钉和套管)。我们使用逻辑回归分析,以 BPTB 自体移植物作为参照组,调整年龄、性别和体重指数后,评估术后 90 天深部感染的可能性。计算需要暴露的人数(NNE)。
在 15671 例 ACLR 中,6745 例(43.0%)使用 BPTB 移植物,2852 例(18.2%)使用 HS 带套管和螺钉固定胫骨,6074 例(38.8%)使用 HS 不带套管和螺钉固定胫骨。术后 90 天发生 38 例(0.2%)深部感染:BPTB 组 11 例(0.2%),HS 带套管和螺钉组 14 例(0.5%),HS 不带套管和螺钉组 13 例(0.2%)。BPTB 组和两组腘绳肌腱组中最常见的感染病原体均为表皮葡萄球菌。与 BPTB ACLR 相比,HS 带套管和螺钉固定组术后 90 天深部感染的可能性更高(比值比 [OR],2.87;95%CI,1.29-6.38)。我们未观察到 HS 不带套管和螺钉固定组与 BPTB ACLR 之间存在差异(OR,1.23;95%CI,0.54-2.77)。HS 带套管和螺钉固定组和 HS 不带套管和螺钉固定组的 NNE 分别为 330 和 2701。
虽然 ACLR 后的总体感染率较低,但当使用套管和螺钉联合固定腘绳肌腱自体移植物时,感染的可能性更高,在进行该手术时应予以考虑。