State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, the Chinese Academy of Sciences, Xining, Qinghai, China.
Microb Drug Resist. 2020 Aug;26(8):857-868. doi: 10.1089/mdr.2019.0200. Epub 2020 Feb 12.
Aspirin is one of the most commonly used nonsteroidal anti-inflammatory drugs. Various potential pharmacological effects of aspirin, such as anticancer, antibacterial activity, and prolonging life expectancy have been discovered. However, the mechanism of aspirin is not fully elucidated. Herein, the effects of aspirin on fatty acid metabolism in yeast cell model were studied. The results showed that aspirin can induce lipid accumulation and reduce the unsaturated fat index in cells. The assessment of cell membrane integrity demonstrated that aspirin caused damage to the cell membrane. These effects of aspirin were attributed to the alterations of the expression of and . Similarly, aspirin was able to cause lipid accumulation and damage to the cell membrane by interfering with the expression of in . These findings are expected to improve current understanding of the mode of action of aspirin and provide a novel strategy for antifungal drug design. Graphical abstract [Figure: see text].
阿司匹林是最常用的非甾体抗炎药之一。已经发现阿司匹林具有多种潜在的药理作用，如抗癌、抗菌活性和延长预期寿命。然而，阿司匹林的作用机制尚未完全阐明。在此，研究了阿司匹林对酵母细胞模型中脂肪酸代谢的影响。结果表明，阿司匹林可诱导脂质积累并降低细胞中的不饱和脂肪指数。细胞膜完整性评估表明，阿司匹林会导致细胞膜损伤。这些阿司匹林的作用归因于 和 的表达变化。同样，阿司匹林通过干扰 在 中的表达，也能引起脂质积累和细胞膜损伤。这些发现有望提高对阿司匹林作用模式的现有理解，并为抗真菌药物设计提供新的策略。 图摘要 [图：见正文]。
