Zi Yingxin, Deng Yu, Ji Meiqi, Qin Yali, Nong Luqi, Liu Ziqiang, Jin Ming
Beijing University of Chinese Medicine.
Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, China.
Medicine (Baltimore). 2020 Feb;99(7):e18618. doi: 10.1097/MD.0000000000018618.
Allergic conjunctivitis (AC) is a multifactorial and common type of ocular surface disease that affects many people. The quality of life for AC patients can be significantly decreased caused by symptoms of ocular itching, swelling, redness, and tearing. Topical antihistaminics, mast cell stabilizers, non-steroidal anti-inflammatory drugs (NSAIDs), and steroids have been widely used to treat AC. Many clinical trials have indicated that olopatadine hydrochloride eye drops can provide quick relief of symptoms and signs. The purpose of this review is to evaluate systematically the effectiveness of olopatadine hydrochloride eye drops for treating AC.
A systematic review of all of the randomized controlled trials on the effectiveness and safety of olopatadine hydrochloride eye drops for AC will be conducted. We will search PubMed, Web of Science (WOS), EMBASE (OVID), the Cochrane Library, Google Scholar, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal database (VIP), Wanfang Database, and CBM, from the database inception date to October 31, 2019. There are no language or publication status restrictions. Registers of clinical trials, potential gray literature, reference lists of studies, and conference abstracts will also be searched. Two reviewers will independently read the articles, extract the data information, and assess the quality of the studies. Data will be synthesized by a heterogeneity test. The primary outcomes include the main symptom and sign scores before and after treatment, the eye redness index, the presence of eosinophils in the conjunctival scraping. Quality of life, the total treatment efficacy, and safety will be evaluated as the secondary outcomes. RevMan V.5.3 software will be used for the meta-analysis.
The study will provide an objective and normative systematic review to evaluate the effectiveness and safety of olopatadine hydrochloride eye drops for the treatment of AC.
Our review will provide useful information to judge whether olopatadine hydrochloride eye drops is an effective intervention for patients with AC.
It is not necessary to obtain ethical approval as participants are not involved patients. The protocol and results will be published in a peer-reviewed journal. The systematic review will also be disseminated electronically and in print to help guide health care practice and policy.
PROSPERO CRD42019132232.
过敏性结膜炎（AC）是一种多因素的常见眼表疾病，影响着许多人。眼部瘙痒、肿胀、发红和流泪等症状会显著降低AC患者的生活质量。局部用抗组胺药、肥大细胞稳定剂、非甾体抗炎药（NSAIDs）和类固醇已被广泛用于治疗AC。许多临床试验表明，盐酸奥洛他定滴眼液能迅速缓解症状和体征。本综述的目的是系统评价盐酸奥洛他定滴眼液治疗AC的有效性。
将对所有关于盐酸奥洛他定滴眼液治疗AC的有效性和安全性的随机对照试验进行系统综述。我们将检索PubMed、科学网（WOS）、EMBASE（OVID）、考克兰图书馆、谷歌学术、中国知网（CNKI）、中国科技期刊数据库（VIP）、万方数据库和中国生物医学文献数据库（CBM），检索时间从各数据库建库之日至2019年10月31日。无语言或发表状态限制。还将检索临床试验注册库、潜在的灰色文献、研究的参考文献列表和会议摘要。两名评价者将独立阅读文章，提取数据信息，并评估研究质量。数据将通过异质性检验进行综合分析。主要结局包括治疗前后的主要症状和体征评分、眼红指数、结膜刮片中嗜酸性粒细胞的存在情况。生活质量、总治疗疗效和安全性将作为次要结局进行评估。将使用RevMan V.5.3软件进行荟萃分析。
本研究将提供客观规范的系统综述，以评估盐酸奥洛他定滴眼液治疗AC的有效性和安全性。
我们的综述将为判断盐酸奥洛他定滴眼液是否为AC患者有效的干预措施提供有用信息。
由于研究未涉及患者，无需获得伦理批准。研究方案和结果将发表在同行评审期刊上。该系统综述还将以电子和印刷形式传播，以帮助指导医疗保健实践和政策制定。
PROSPERO CRD42019132232。
