Ådjers Kati, Luukkainen Annika, Pekkanen Juha, Hurme Mikko, Huhtala Heini, Renkonen Risto, Wang De Yun, Mäkelä Mika J, Karjalainen Jussi, Toppila-Salmi Sanna
Department of Ophthalmology, Hatanpää Hospital, Tampere, Finland.
Int Arch Allergy Immunol. 2017;172(2):123-128. doi: 10.1159/000456009. Epub 2017 Mar 9.
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
A population-based sample of Finnish adult asthma patients (n = 1,156) and matched controls (n = 1,792) filled in a questionnaire. Asthma was diagnosed based on a typical history of asthma symptoms and lung function tests. Skin prick tests with 17 aeroallergens and blood tests including analysis of interleukin 13 (IL13) rs20541 (G/A) genotypes were performed for a subsample (n = 193).
The proportion of asthmatics reporting AR was 61.9% and reporting AC was 40.7%. After adjustments, the presence of the IL13 rs20541A- allele (OR 3.06, 95% CI 1.42-6.58, p = 0.004) or multisensitization (adjusted OR 4.59, 95% CI 1.48-14.26, p = 0.008) was associated with AR/AC asthma. Nasal polyps and acetylsalicylic acid-exacerbated respiratory disease was also associated with AR/AC asthma.
Adult AR/AC asthma could putatively be a phenotype, characterized by the presence of atopic and/or eosinophilic factors and a high prevalence of the IL13 rs20541A- allele. Studies on the mechanisms behind this and in other populations are needed.
我们的目的是观察成年哮喘患者中与白细胞介素13（IL13）rs20541多态性相关的因素，以及其他伴有或不伴有过敏性合并症（如受试者自述的过敏性鼻炎（AR）和/或过敏性结膜炎（AC）症状）的因素。
以芬兰成年哮喘患者（n = 1156）和匹配的对照组（n = 1792）为基础的样本填写了一份问卷。根据典型的哮喘症状病史和肺功能测试诊断哮喘。对一个子样本（n = 193）进行了17种空气过敏原的皮肤点刺试验和包括白细胞介素13（IL13）rs20541（G/A）基因型分析在内的血液检测。
自述患有AR的哮喘患者比例为61.9%，自述患有AC的为40.7%。调整后，IL13 rs20541A等位基因的存在（比值比3.06，95%置信区间1.42 - 6.58，p = 0.004）或多重致敏（调整后比值比4.59，95%置信区间1.48 - 14.26，p = 0.008）与AR/AC哮喘相关。鼻息肉和阿司匹林诱发的呼吸道疾病也与AR/AC哮喘相关。
成年AR/AC哮喘可能是一种表型，其特征为存在特应性和/或嗜酸性粒细胞相关因素以及IL13 rs20541A等位基因的高患病率。需要对这背后的机制以及其他人群进行研究。
