Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
J Reprod Immunol. 2020 Apr;138:103099. doi: 10.1016/j.jri.2020.103099. Epub 2020 Feb 4.
Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive cells. Extravillous cytotrophoblast invasion was present in the myometrium which was not covered by the decidual tissue whereas myometrial invasion of cytotrophoblasts was absent where this tissue lay deep to decidua. These results suggest that indoleamine 2,3-dioxygenase expression in the decidua may normally control trophoblast invasion and absence of its expression where decidua is absent may be involved in the pathogenesis of the over-invaded placenta.
为了更好地理解胎盘植入谱的病理生理学，研究了吲哚胺 2,3-双加氧酶的免疫组织化学定位。在蜕膜中发现吲哚胺 2,3-双加氧酶染色位于腺上皮中，并有一些额外的阳性细胞。绒毛外滋养细胞浸润存在于未被蜕膜覆盖的子宫肌层中，而在蜕膜深面的子宫肌层中不存在滋养细胞浸润。这些结果表明，蜕膜中吲哚胺 2,3-双加氧酶的表达可能正常控制滋养细胞的浸润，而在蜕膜缺失的部位其表达缺失可能与过度浸润的胎盘的发病机制有关。
