Department of Human Genetics, Ruhr-University, Bochum, Germany.
Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University, Bochum, Germany.
J Neuroimmunol. 2020 Apr 15;341:577187. doi: 10.1016/j.jneuroim.2020.577187. Epub 2020 Feb 5.
Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the pathogenic events underlying autoimmunity. Assessing TL in whole blood DNA samples in 138 MS patients and 120 healthy controls showed reduced TL in patients as compared with controls There seems to be a prelude of accelerated telomere shortening, which may increase the risk for development of MS.
相对端粒长度 (TL) 被视为生物年龄的生物标志物。在包括多发性硬化症 (MS) 在内的自身免疫性疾病中，已经证明了 TL 减少代表的免疫衰老加速。然而，端粒缩短是自身免疫潜在致病事件的原因还是后果仍未解决。在 138 名 MS 患者和 120 名健康对照者的全血 DNA 样本中评估 TL 显示，与对照组相比，患者的 TL 降低。似乎存在加速端粒缩短的前奏，这可能会增加 MS 发展的风险。
