Department of Psychology, University of Bologna, Bologna, Italy.
Department of Psychiatry, University at Buffalo, State University of New York, Buffalo, New York, USA.
Psychother Psychosom. 2020;89(2):74-89. doi: 10.1159/000506110. Epub 2020 Feb 12.
Patient-reported outcomes (PROs) are of increasing importance in clinical medicine. However, their evaluation by classic psychometric methods carries considerable limitations. The clinimetric approach provides a viable framework for their assessment.
The aim of this paper was to provide a systematic review of clinimetric properties of the Symptom Questionnaire (SQ), a simple, self-rated instrument for the assessment of psychological symptoms (depression, anxiety, hostility, and somatization) and well-being (contentment, relaxation, friendliness, and physical well-being).
The PRISMA guidelines were used. Electronic databases were searched from inception up to March 2019. Only original research articles, published in English, reporting data about the clinimetric properties of the SQ, were included.
A total of 284 studies was selected. The SQ has been used in populations of adults, adolescents, and older individuals. The scale significantly discriminated between subgroups of subjects in both clinical and nonclinical settings, and differentiated medical and psychiatric patients from healthy controls. In longitudinal studies and in controlled pharmacological and psychotherapy trials, it was highly sensitive to symptoms and well-being changes and discriminated between the effects of psychotropic drugs and placebo.
The SQ is a highly sensitive clinimetric index. It may yield clinical information that similar scales would fail to provide and has a unique position among the PROs that are available. Its use in clinical trials is strongly recommended.
患者报告的结局（PROs）在临床医学中越来越重要。然而，经典心理计量学方法对其评估存在相当大的局限性。临床计量学方法为其评估提供了可行的框架。
本文旨在系统评价症状问卷（SQ）的临床计量学特性，SQ 是一种简单的自评工具，用于评估心理症状（抑郁、焦虑、敌意和躯体化）和幸福感（满足感、放松、友善和身体幸福感）。
使用 PRISMA 指南。从创建到 2019 年 3 月，对电子数据库进行了搜索。仅纳入了发表英文原始研究文章，报告 SQ 临床计量学特性数据的研究。
共选择了 284 项研究。SQ 已在成年、青少年和老年人人群中使用。该量表在临床和非临床环境中，均能显著区分亚组人群，能区分医学和精神科患者与健康对照者。在纵向研究和对照药理学及心理治疗试验中，它对症状和幸福感的变化高度敏感，并能区分精神药物和安慰剂的作用。
SQ 是一种高度敏感的临床计量学指标。它可能提供类似量表无法提供的临床信息，在现有的 PROs 中具有独特的地位。强烈建议在临床试验中使用。
