Ophthalmology, Changhua Christian Hospital, Changhua City, Taiwan.
Ophthalmology, Changhua Christian Hospital Yunlin Branch, Xiluo, Yunlin, Taiwan.
Br J Ophthalmol. 2020 Nov;104(11):1561-1566. doi: 10.1136/bjophthalmol-2019-315302. Epub 2020 Feb 12.
This study aimed to report the 3-year follow-up results of the clinical course and structural changes of choroidal neovascularisation (CNV) by optical coherence tomography angiography (OCT-A) in eyes with a history of chronic central serous chorioretinopathy (CSC).
This is a retrospective study of patients with chronic CSC complicated with CNV. Patients were recorded of best-corrected visual acuity (BCVA) and treatment modalities. OCT was used to evaluate the presence of subretinal fluid (SRF), type of CNV, changes in central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT). Changes in the size, vessel density (VD) and morphology of CNV were evaluated by OCT-A. Comparison between baseline and final parameters was made.
A total of 30 eyes in 26 patients, most of whom had previous treatment for chronic CSC, were included with a mean follow-up period of 40.37±4.11 months. No changes in BCVA were noted (p=0.562). During the 3-year follow-up period with OCT-A, five eyes had SRF noted. The other 25 eyes remained SRF free throughout the course. Regarding the morphological changes, the size of CNV enlarged significantly (p<0.01); VD of CNV decreased significantly (p=0.01); and the number of CNV with visible core vessel significantly increased (p<0.01). A significant reduced SFCT was noted (p=0.02), while the CRT remained unchanged (p=0.855).
For most eyes infected with chronic CSC receiving previous treatment for the activity of chronic CSC, with CNV subsequently found on OCT-A, a midterm stable clinical course up to 3 years was noted, despite significant structural changes of CNV evaluated by OCT-A.
本研究旨在报告光学相干断层扫描血管造影（OCT-A）对既往有慢性中心性浆液性脉络膜视网膜病变（CSC）病史的脉络膜新生血管（CNV）患者的临床病程和结构变化的 3 年随访结果。
这是一项回顾性研究，纳入了患有慢性 CSC 合并 CNV 的患者。记录了患者最佳矫正视力（BCVA）和治疗方式。使用 OCT 评估是否存在视网膜下液（SRF）、CNV 类型、中心视网膜厚度（CRT）和中心凹下脉络膜厚度（SFCT）的变化。通过 OCT-A 评估 CNV 的大小、血管密度（VD）和形态的变化。比较了基线和最终参数。
共纳入 26 例患者的 30 只眼，大多数患者曾接受过慢性 CSC 的治疗，平均随访时间为 40.37±4.11 个月。BCVA 无变化（p=0.562）。在 3 年的 OCT-A 随访期间，有 5 只眼出现了 SRF。其余 25 只眼在整个病程中均无 SRF。在形态学变化方面，CNV 的大小显著增大（p<0.01）；CNV 的 VD 显著降低（p=0.01）；可见核心血管的 CNV 数量显著增加（p<0.01）。SFCT 显著降低（p=0.02），而 CRT 保持不变（p=0.855）。
对于大多数既往接受过慢性 CSC 活动治疗、随后在 OCT-A 上发现 CNV 的慢性 CSC 感染眼，尽管 OCT-A 评估的 CNV 结构变化显著，但在 3 年内观察到中期稳定的临床病程。
