Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
Am J Ophthalmol. 2018 Sep;193:80-86. doi: 10.1016/j.ajo.2018.06.009. Epub 2018 Jun 27.
To evaluate the type 1 choroidal neovascularization (CNV) incidence and associated factors in eyes with central serous chorioretinopathy (CSC).
Retrospective case series.
Records of 363 eyes (324 patients) with CSC were reviewed. Age, sex, CSC type, choroidal vascular hyperpermeability (CVH), best-corrected visual acuity (BCVA), subfoveal choroidal thickness (SCT), and systemic hypertension (HT) were assessed and compared between subjects with and without neovascular CSC.
We identified 219 and 144 eyes with chronic and acute CSC, respectively. The mean participant age was 55.2 ± 12.0 years, and 58 (15.6%) eyes had neovascular CSC. Age (no CNV: 54.8 ± 12.1 years, CNV: 57.3 ± 10.9 years; P = .118) and SCT (no CNV: 388.0 ± 104.5 μm, CNV: 377.4 ± 108.9 μm; P = .487) were comparable between eyes with and without CNV. However, BCVA (logarithm of the minimum angle of resolution) was significantly worse in subjects with CNV (0.28 ± 0.33 [20/38] vs 0.15 ± 0.29 [20/28]; P = .014). Neovascular CSC occurred more often in women (72 [23.6%] vs 20 [34.5%], P = .099) and in cases of chronic CSC (171 [56.1%] vs 48 [82.8%], P < .001), CVH (205 [67.2%] vs 58 [100%], P < .001), and HT (91 [29.8%] vs 24 [41.4%], P = .092). Chronic CSC (P = .001), female sex (P = .075), and poor BCVA (P = .091) were associated with neovascular CSC (multiple regression).
Chronic CSC, female sex, CVH, and poor BCVA are risk factors for CNV in eyes with CSC.
评估中心性浆液性脉络膜视网膜病变（CSC）患者 1 型脉络膜新生血管（CNV）的发生率及相关因素。
回顾性病例系列。
对 363 只眼（324 例患者）的 CSC 记录进行了回顾。评估并比较了有和无新生血管性 CSC 的患者的年龄、性别、CSC 类型、脉络膜血管通透性增加（CVH）、最佳矫正视力（BCVA）、中心凹下脉络膜厚度（SCT）和高血压（HT）。
我们分别确定了 219 只和 144 只慢性和急性 CSC 的眼。平均参与者年龄为 55.2±12.0 岁，58 只（15.6%）眼有新生血管性 CSC。年龄（无 CNV：54.8±12.1 岁，CNV：57.3±10.9 岁；P=0.118）和 SCT（无 CNV：388.0±104.5μm，CNV：377.4±108.9μm；P=0.487）在有和无 CNV 的眼中相似。然而，CNV 患者的 BCVA（最小分辨角对数）明显更差（0.28±0.33[20/38]与 0.15±0.29[20/28]；P=0.014）。新生血管性 CSC 更常见于女性（72[23.6%]与 20[34.5%]，P=0.099）和慢性 CSC（171[56.1%]与 48[82.8%]，P<0.001）、CVH（205[67.2%]与 58[100%]，P<0.001）和 HT（91[29.8%]与 24[41.4%]，P=0.092）。慢性 CSC（P=0.001）、女性（P=0.075）和 BCVA 差（P=0.091）是 CSC 患者发生新生血管性 CSC 的相关因素（多元回归）。
慢性 CSC、女性、CVH 和较差的 BCVA 是 CSC 患者发生 CNV 的危险因素。
