Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon-si, Korea.
Department of Neurology, Uijeongbu St.Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea.
Sci Rep. 2020 Feb 12;10(1):2428. doi: 10.1038/s41598-020-59366-9.
Although many patients with cluster headaches (CH) are disabled by their condition, few studies have examined this in detail. This cross-sectional, multicenter observational study prospectively collected demographic and clinical questionnaire data from 224 consecutive patients with CH. We assessed headache impact using the six-item Headache Impact Test (HIT-6) and evaluated the factors associated with the impact of CH. Participants with a HIT-6 score ≥ 60 were classified into a severe impact group. The majority (190, 84.8%) of the participants were classified into the severe impact group. These patients were characterized by younger age, earlier onset of CH, longer duration of each headache attack, higher pain intensity, more cranial autonomic symptoms, a higher proportion of depression or anxiety, higher score of stress, and lower score of quality of life. The anxiety (OR = 1.19, 95% CI: 1.08-1.31, p = 0.006), greater pain intensity (OR = 1.06, 95% CI: 1.02-1.10, p = 0.002), and age (OR = 0.99, 95% CI: 0.99-1.00, p = 0.008) were significant predictors for a severe impact of CH patients. According to the HIT-6 results, most of the CH patients were significantly affected by CH. As well as pain intensity, anxiety and age modulated CH's impact on their lives.
尽管许多丛集性头痛（CH）患者的病情使他们丧失了工作能力，但很少有研究对此进行详细探讨。这项横断面、多中心观察性研究前瞻性地从 224 例连续 CH 患者中收集人口统计学和临床问卷数据。我们使用六分量表头痛影响测试（HIT-6）评估头痛影响，并评估与 CH 影响相关的因素。HIT-6 评分≥60 的参与者被分类为严重影响组。大多数（190 例，84.8%）参与者被分类为严重影响组。这些患者的特点是年龄较小、CH 发病较早、每次头痛发作持续时间较长、疼痛强度较高、更多的颅自主神经症状、更高比例的抑郁或焦虑、更高的压力评分以及较低的生活质量评分。焦虑（OR=1.19，95%CI：1.08-1.31，p=0.006）、更大的疼痛强度（OR=1.06，95%CI：1.02-1.10，p=0.002）和年龄（OR=0.99，95%CI：0.99-1.00，p=0.008）是 CH 患者严重影响的显著预测因素。根据 HIT-6 的结果，大多数 CH 患者的病情明显受到 CH 的影响。除了疼痛强度外，焦虑和年龄也调节了 CH 对其生活的影响。
