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Extracellular vesicles from myelodysplastic mesenchymal stromal cells induce DNA damage and mutagenesis of hematopoietic stem cells through miRNA transfer.

作者信息

Meunier Mathieu, Guttin Audrey, Ancelet Sarah, Laurin David, Zannoni Johanna, Lefebvre Christine, Tondeur Sylvie, Persoons Virginie, Pezet Mylène, Pernet-Gallay Karin, Chuffart Florent, Rousseaux Sophie, Testard Quentin, Thevenon Julien, Jouzier Claire, Deleuze Jean-François, Laulagnier Karine, Sadoul Rémy, Chatellard Christine, Hainaut Pierre, Polack Benoît, Cahn Jean-Yves, Issartel Jean-Paul, Park Sophie

机构信息

Department of Hematology, CHU Grenoble Alpes, Grenoble, France.

CNRS UMR 5309, INSERM, U1209, Université Grenoble Alpes, Institute for Advanced Bioscience, 38700, Grenoble, France.

出版信息

Leukemia. 2020 Aug;34(8):2249-2253. doi: 10.1038/s41375-020-0738-8. Epub 2020 Feb 12.

DOI:10.1038/s41375-020-0738-8
PMID:32051530
Abstract
摘要

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本文引用的文献

1
Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes.活性氧水平通过低剂量地拉罗司控制低危骨髓增生异常综合征红系祖细胞中NF-κB的激活。
Oncotarget. 2017 Nov 6;8(62):105510-105524. doi: 10.18632/oncotarget.22299. eCollection 2017 Dec 1.
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Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.细胞外囊泡通讯：我们的现状与未来展望。
Cell. 2016 Mar 10;164(6):1226-1232. doi: 10.1016/j.cell.2016.01.043.
3
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
骨髓间充质干细胞衍生细胞外囊泡的全球 miRNA 分析鉴定与再生障碍性贫血造血功能障碍相关的 miRNA。
Sci Rep. 2024 Aug 23;14(1):19654. doi: 10.1038/s41598-024-70369-8.
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Extracellular microvesicles: biologic properties, biogenesis, and applications in leukemia.细胞外微泡：生物学特性、生物发生及其在白血病中的应用
Mol Cell Biochem. 2024 Feb;479(2):419-430. doi: 10.1007/s11010-023-04734-y. Epub 2023 Apr 21.
5
Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes.骨髓增生异常综合征中的细胞外囊泡和 microRNA。
Cells. 2023 Feb 19;12(4):658. doi: 10.3390/cells12040658.
6
Extracellular Vesicles in Myeloid Neoplasms.髓系肿瘤细胞外囊泡。
Int J Mol Sci. 2022 Aug 8;23(15):8827. doi: 10.3390/ijms23158827.
7
Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells.间充质干细胞对恶性髓系白血病的调控
Front Cell Dev Biol. 2022 Jun 8;10:857045. doi: 10.3389/fcell.2022.857045. eCollection 2022.
8
Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology.探讨 DROSHA 突变在肿瘤血液学中的致病性。
Cells. 2021 Sep 8;10(9):2357. doi: 10.3390/cells10092357.
9
Targeting the Microenvironment in MDS: The Final Frontier.靶向骨髓增生异常综合征的微环境：最后的前沿领域。
Front Pharmacol. 2020 Jul 9;11:1044. doi: 10.3389/fphar.2020.01044. eCollection 2020.
微小RNA-486-5p是唐氏综合征髓系白血病的一种红系癌基因miRNA。
Blood. 2015 Feb 19;125(8):1292-301. doi: 10.1182/blood-2014-06-581892. Epub 2014 Dec 22.
4
DICER1: mutations, microRNAs and mechanisms.DICER1 突变、microRNAs 及机制
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5
Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells.MDS 中基质支持不足是由于间充质基质细胞的分子和功能缺陷所致。
Leukemia. 2013 Sep;27(9):1841-51. doi: 10.1038/leu.2013.193. Epub 2013 Mar 29.
6
miR-486-5p induces replicative senescence of human adipose tissue-derived mesenchymal stem cells and its expression is controlled by high glucose.miR-486-5p 诱导人脂肪组织来源间充质干细胞复制性衰老，其表达受高糖调控。
Stem Cells Dev. 2012 Jul 1;21(10):1749-60. doi: 10.1089/scd.2011.0429. Epub 2011 Nov 21.
7
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.骨祖细胞功能障碍导致骨髓增生异常和继发性白血病。
Nature. 2010 Apr 8;464(7290):852-7. doi: 10.1038/nature08851. Epub 2010 Mar 21.