Ashoub Muhammad Hossein, Salavatipour Maryam Samareh, Kasgari Fatemeh Hoseinpour, Valandani Hajar Mardani, Khalilabadi Roohollah Mirzaee
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran.
Mol Cell Biochem. 2024 Feb;479(2):419-430. doi: 10.1007/s11010-023-04734-y. Epub 2023 Apr 21.
Microvesicles are cellular membrane vesicles of which size is limited to 30-1000 nm. Almost all cells release them in response to activation signals and apoptosis. Their ability for intercellular communication and enhancement of potential for information exchange (between them) has attracted much interest. Their content is affected by the content of the mother cell, which can help identify their origin. Furthermore, these particles can change the physiology of the target cells by transferring a set of molecules to them and changing the epigenetics of the cells by transferring DNA and RNA. These changes can be induced in cells close to the mother and distant cells. Significant activities of these microvesicles are known both in physiological and pathologic conditions. In this regard, we have reviewed these small particle elements, their contents, and the way of synthesis. Finally, we discussed their current known roles to reveal more potential applications in leukemia.
微泡是细胞膜囊泡，其大小限制在30 - 1000纳米。几乎所有细胞都会在激活信号和细胞凋亡的刺激下释放微泡。它们进行细胞间通讯以及增强（细胞间）信息交换潜力的能力引起了广泛关注。其内容物受母细胞内容物的影响，这有助于确定它们的来源。此外，这些颗粒可以通过向靶细胞转移一组分子来改变靶细胞的生理学，并通过转移DNA和RNA来改变细胞的表观遗传学。这些变化可在靠近母细胞的细胞以及远处的细胞中诱导产生。这些微泡在生理和病理条件下都具有显著活性。在这方面，我们综述了这些小颗粒成分、它们的内容物以及合成方式。最后，我们讨论了它们目前已知的作用，以揭示其在白血病中更多的潜在应用。
