Piccicuto Virginie, Dincer Zuhal, Walker Suzanne, Gray Christopher
Pathology Department,Covance Laboratories Limited, Otley road, Harrogate, HG3 1PY, United Kingdom.
Toxicology Department, Covance Laboratories Limited, Otley road, Harrogate, HG3 1PY, United Kingdom.
J Toxicol Pathol. 2020 Jan;33(1):29-32. doi: 10.1293/tox.2019-0059. Epub 2019 Dec 5.
This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a thin fibrous stroma and minimal lympho-plasmacytic and neutrophilic infiltrate in the apex of the heart. Immunohistopathology using CD31 confirmed the blood vessel origin, and using Ki67 confirmed low cell-proliferative activity in the vascular endothelial cells. To the authors' knowledge, this is the first report of spontaneous angiomatous hyperplasia in the heart of a young rat.
本病例报告描述了一只年轻雄性斯普拉格-道利大鼠在短期毒性研究中，心脏出现血管瘤样增生，这是一个不寻常的部位。组织学上，病变的特征是有直径不一、充满血液的血管通道，其内壁为薄壁，周围是薄的纤维性基质，且在心脏顶端有少量淋巴细胞、浆细胞和中性粒细胞浸润。使用CD31进行免疫组织病理学检查证实了血管起源，使用Ki67证实血管内皮细胞的细胞增殖活性较低。据作者所知，这是年轻大鼠心脏自发性血管瘤样增生的首次报告。
