Awazuhara Yuumi, Tomonari Yuki, Kokoshima Hiroko, Wako Yumi, Doi Takuya
Pathology Department, Kashima Laboratories, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.
Current affiliation: Pathology Department, Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima-shi, Kagoshima 891-1394, Japan.
J Toxicol Pathol. 2025 Jan;38(1):37-42. doi: 10.1293/tox.2024-0007. Epub 2024 Sep 13.
We performed morphological and immunohistochemical analyses of erythrocyte-rich vascular proliferative lesions of mesenteric lymph nodes in six male and one female Wistar Hannover rats. These lesions are conventionally diagnosed as hemangiomas due to abundant erythrocytes. Immunostaining was positive for prospero-related homeobox 1 (Prox-1) and/or vascular endothelial growth factor receptor 3 (VEGFR3) in all lesions, suggesting a lymphangitic origin. In 6 of 7 lesions, von Willebrand factor (vWF) immunostaining was negative, suggesting a non-blood vascular origin. These results demonstrated that almost all hemangiomas in rat mesenteric lymph nodes were lymphangiomas. To the best of our knowledge, this is the first report highlighting the lymphatic origin of vascular proliferative lesions in the mesenteric lymph nodes of rats.
我们对6只雄性和1只雌性Wistar Hannover大鼠肠系膜淋巴结中富含红细胞的血管增生性病变进行了形态学和免疫组织化学分析。由于这些病变中红细胞丰富，传统上被诊断为血管瘤。所有病变中prospero相关同源盒1（Prox-1）和/或血管内皮生长因子受体3（VEGFR3）免疫染色均为阳性，提示淋巴管起源。在7个病变中的6个中，血管性血友病因子（vWF）免疫染色为阴性，提示非血管起源。这些结果表明，大鼠肠系膜淋巴结中的几乎所有血管瘤均为淋巴管瘤。据我们所知，这是首次报道强调大鼠肠系膜淋巴结血管增生性病变的淋巴管起源。
