Shapiro Joshua A, AbuMoussa Samuel, Lindsay Christopher P, Mason Gabriel B, Dahners Laurence E, Weinhold Paul S
Department of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA.
J Orthop. 2019 Dec 12;20:213-216. doi: 10.1016/j.jor.2019.12.007. eCollection 2020 Jul-Aug.
The purpose of this study was to determine whether intramedullary administration of extended-release minocycline microspheres would affect osseointegration.
Twenty-two rats were randomized to minocycline or saline femoral intramedullary injection followed by implantation of titanium alloy rods. Following euthanasia at four-weeks, pushout testing was performed and bone-volume-fraction assessed.
Pushout strength was marginally greater in minocycline-treated implants (122.5 ± 39.1 N) compared to saline (96.9 ± 26.1 N) (P = 0.098). No difference was observed in energy to maximum load, mean stiffness, or peri-implant bone-volume-fraction (P > 0.05).
Peri-implant minocycline administration did not impair implant fixation strength or peri-implant bone-volume, supporting its potential utility as an adjunct to intramedullary implants.
本研究的目的是确定髓内注射缓释米诺环素微球是否会影响骨整合。
将22只大鼠随机分为米诺环素组或生理盐水组，进行股骨髓内注射，随后植入钛合金棒。四周后安乐死大鼠，进行推出试验并评估骨体积分数。
与生理盐水组（96.9±26.1 N）相比，米诺环素处理组植入物的推出强度略高（122.5±39.1 N）（P = 0.098）。在最大负荷能量、平均刚度或种植体周围骨体积分数方面未观察到差异（P>0.05）。
种植体周围给予米诺环素不会损害种植体固定强度或种植体周围骨体积，支持其作为髓内植入物辅助剂的潜在效用。
