Kasper Stefan, Virchow Isabel, Hadaschik Boris, Radtke Jan Philipp
Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
Klinik für Urologie, Kinderurologie und Uroonkologie, Westdeutsches Tumorzentrum, Universitätsklinikum Essen, Essen, Deutschland.
Radiologe. 2020 May;60(5):421-429. doi: 10.1007/s00117-020-00653-x.
Positron-emission tomography/computed tomography (PET/CT) and positron-emission tomography/magnetic resonance imaging (PET/MRI) are hybrid medical imaging techniques that are becoming increasingly important in the diagnostic workup of cancer. Correct definition and interpretation of results are key challenges for both radiologists/specialists in nuclear medicine as well as for the treating clinician. Strong interdisciplinary communication is prerequisite to solve the upcoming complexity of retrieved information generated by hybrid imaging.
Different indications for hybrid medical imaging and review of current theranostic principles from the perspective of clinicians/clinical oncologists.
The GBA guidelines and recommendations retrieved from the corresponding German S3 guidelines for the use of PET imaging are summarized, followed by a review of innovative clinical trials that promote PET-based therapeutic strategies and radioligand therapies.
Next generation PET/CT and PET/MRI imaging are being increasingly used for diagnostic purposes and follow-up staging in malignant tumors. Radioligand therapy may have the potential to be a further cornerstone in personalized antitumor therapy.
Careful implementation of hybrid medical imaging can clearly improve the quality of the diagnosis in cancer patients and even increase the quality of care for cancer patients. Close interdisciplinary collaboration is essential to optimize therapeutic strategies for each patient.
正电子发射断层扫描/计算机断层扫描(PET/CT)和正电子发射断层扫描/磁共振成像(PET/MRI)是混合医学成像技术,在癌症诊断检查中变得越来越重要。正确定义和解读结果是放射科医生/核医学专家以及治疗临床医生面临的关键挑战。强大的跨学科沟通是解决混合成像产生的日益复杂的检索信息的先决条件。
从临床医生/临床肿瘤学家的角度探讨混合医学成像的不同适应证并回顾当前的诊疗一体化原则。
总结从德国相应的PET成像使用S3指南中检索到的GBA指南和建议,随后回顾促进基于PET的治疗策略和放射性配体疗法的创新临床试验。
新一代PET/CT和PET/MRI成像越来越多地用于恶性肿瘤的诊断目的和随访分期。放射性配体疗法可能成为个性化抗肿瘤治疗的又一个基石。
谨慎实施混合医学成像可明显提高癌症患者的诊断质量,甚至提升癌症患者的护理质量。密切的跨学科合作对于优化每位患者的治疗策略至关重要。