Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.
Department of Rhinology, Hana ENT Hospital, Seoul, Korea.
Clin Exp Allergy. 2020 May;50(5):585-596. doi: 10.1111/cea.13586. Epub 2020 Feb 28.
Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age-related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine.
The objective of this study was to characterize age-related changes in immunologic profiles according to CRS subtypes.
Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non-eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed.
In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age-related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age-related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age-related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age-associated increases in type 1/2/3 mediators as well as CT scores. These age-related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration.
Age-associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP.
固有免疫和适应性免疫的免疫功能随年龄的增长而变化。因此，需要研究慢性鼻-鼻窦炎（CRS）中与年龄相关的细胞因子谱，以实现精准医疗。
本研究旨在根据 CRS 亚型描述免疫谱与年龄相关的变化。
本研究纳入了对照组（n=29）、非鼻息肉型 CRS（CRSsNP，n=86）和鼻息肉型 CRS（嗜酸性鼻息肉：ENP，n=81；非嗜酸性鼻息肉：NENP，n=113）患者。对鼻黏膜组织匀浆中的 20 种 1/2/3 型炎症和其他炎症过程的标志物进行了测量，并进行了统计学分析。
在对照组组织中，2 型/3 型和促炎介质与年龄呈负相关。CRSsNP 和 NENP 表现出与年龄相关的 2 型细胞因子增加和 3 型细胞因子减少。有趣的是，NENP 中与 CT 评分相关的 3 型介质的年龄相关性下降与 CT 评分相关。ENP 表现出与年龄相关的 3 型细胞因子增加，而 2 型介质保持在较高水平。ENP 吸烟者表现出与年龄相关的 1/2/3 型介质和 CT 评分的增加。这些在每个 CRS 中与年龄相关的模式在统计学上通过调整过敏状态、吸烟史和疾病持续时间得到了证实。
CRS 亚型和对照组织的与年龄相关的细胞因子变化不同。CRSsNP 和 NENP 表现出 3 型介质减少和 2 型介质增加，而 ENP 中 3 型介质随年龄增加。
