Koyama S, Nishimura T, Kubokura T, Sannoh N, Tsubone K
Division of Neurosurgery, Ushioda General Hospital, Yokohama, Japan.
No Shinkei Geka. 1988 Sep;16(10):1179-85.
A case is reported of a 71-year-old female with cervical myelopathy caused by calcified nodules in the cervical ligamentum flavum and improved by en bloc laminectomy. The calcified nodules were formed by the deposition of two crystals, hydroxyapatite (HAP) and calcium pyrophosphate dihydrate (CPPD). Light microscopy, scanning electron microscopy, energy dispersive X-ray microanalysis and X-ray diffraction study disclosed that the larger nodule located on the right was composed mainly of HAP in the central part and CPPD in the circumference. On the other hand, the smaller nodule located on the left was composed mainly of CPPD crystal. These findings support the hypothesis that calcification of the ligamentum flavum and CPPD crystal deposition disease in the cervical region are the same entity and the both are merely different aspects of the same entity at different chronological stages.
报告了一例71岁女性因颈椎黄韧带钙化结节导致颈椎脊髓病，经整块椎板切除术病情改善的病例。钙化结节由两种晶体沉积形成，即羟基磷灰石（HAP）和二水焦磷酸钙（CPPD）。光学显微镜、扫描电子显微镜、能量色散X射线微分析和X射线衍射研究表明，位于右侧的较大结节中央主要由HAP组成，周边由CPPD组成。另一方面，位于左侧的较小结节主要由CPPD晶体组成。这些发现支持了这样一种假说，即颈椎黄韧带钙化和颈椎区域的CPPD晶体沉积病是同一实体，两者只是同一实体在不同时间阶段的不同表现。
