Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Biomed Mater. 2020 Apr 28;15(3):035018. doi: 10.1088/1748-605X/ab763c.
Modification of the surface of titanium into titania (TiO) nanotube (TNT) arrays was performed by electrochemical anodization to design an endoprosthesis for maxillofacial surgery. TNT arrays with different surface structures were successfully coated on titanium substrates by varying the anodizing voltages and annealed at 450 °C for 4 h. The phase composition and morphology of the nanotubes were examined by x-ray powder diffraction and field-emission scanning electron microscopy, respectively. The biological functions and water wettability of various surface structures were also investigated. The results demonstrated that the annealed nanotubes were composed of an anatase phase only at all applied voltages. The tube diameters and lengths increased as the voltage increased. The surfaces with modification had more wettability, cell adhesion, proliferation, alkaline phosphatase activity and calcium deposition than the surfaces without modification. Finally, the results demonstrated that a modified surface of titanium to produce TNT arrays as a biomaterial is promising to design an osseointegrated surface of endoprosthesis for maxillofacial surgery.
通过电化学阳极氧化将钛表面改性为二氧化钛（TiO）纳米管（TNT）阵列，旨在为颌面外科设计一种内假体。通过改变阳极氧化电压，成功地在钛基底上涂覆了具有不同表面结构的 TNT 阵列，并在 450°C 下退火 4 小时。通过 X 射线粉末衍射和场发射扫描电子显微镜分别检查了纳米管的相组成和形态。还研究了各种表面结构的生物功能和润湿性。结果表明，在所有应用电压下，退火后的纳米管仅由锐钛矿相组成。随着电压的增加，管的直径和长度增加。改性后的表面比未改性的表面具有更好的润湿性、细胞黏附性、增殖能力、碱性磷酸酶活性和钙沉积。最后，结果表明，用钛来制备 TNT 阵列的改性表面作为生物材料，有望设计出用于颌面外科的与骨整合的内假体表面。
