Bell J, Bickford-Wimer P C, de la Garza R, Egan M, Freedman R
Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.
Neuropharmacology. 1988 Nov;27(11):1187-90. doi: 10.1016/0028-3908(88)90016-0.
Spontaneous discharge rates of cerebellar Purkinje neurons were decreased in rats withdrawn from chronic treatment with alprazolam, diazepam, and lorazepam relative to discharge rates recorded from control rats. Prior treatment with 6-hydroxydopamine to deplete cerebellar levels of norepinephrine significantly reduced this effect of diazepam upon Purkinje cell firing rates. The data suggest that increased noradrenergic activity may be occurring during withdrawal from benzodiazepines.
与对照组大鼠记录的放电率相比，长期接受阿普唑仑、地西泮和劳拉西泮治疗后停药的大鼠，小脑浦肯野神经元的自发放电率降低。事先用6-羟基多巴胺耗竭小脑去甲肾上腺素水平，可显著降低地西泮对浦肯野细胞放电率的这种作用。数据表明，在苯二氮卓类药物戒断期间，去甲肾上腺素能活性可能增强。
