Costall B, Kelly M E, Onaivi E S, Naylor R J
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, UK.
Naunyn Schmiedebergs Arch Pharmacol. 1990 Jun;341(6):547-51. doi: 10.1007/BF00171735.
Ketotifen was compared to diazepam to inhibit aversive responding of the mouse in a black and white test box and in the rat social interaction test. Both drugs reduced aversive responding in the mouse to the brightly illuminated area of the test box and facilitated social interaction in the rat; ketotifen was approximately 100 times more potent than diazepam. The chronic administration of diazepam, ethanol, nicotine and cocaine in the mouse also reduced aversive responding but their withdrawal was associated with an increased behavioural suppression. The administration of ketotifen during the period of withdrawal from diazepam, ethanol, nicotine and cocaine prevented the exacerbation in aversive responding. It is concluded that ketotifen, like diazepam and 5-HT3 receptor antagonists, can reduce behavioural suppression in rodent models of anxiety and attenuate the behavioural consequences of withdrawal from treatment with drugs of abuse.
在黑白测试箱中对小鼠进行厌恶性反应抑制试验，并在大鼠社交互动试验中，将酮替芬与地西泮进行了比较。两种药物均能减少小鼠对测试箱明亮照明区域的厌恶性反应，并促进大鼠的社交互动；酮替芬的效力约为地西泮的100倍。在小鼠中长期给予地西泮、乙醇、尼古丁和可卡因也能减少厌恶性反应，但撤药后会出现行为抑制增强。在从地西泮、乙醇、尼古丁和可卡因撤药期间给予酮替芬，可防止厌恶性反应加剧。得出的结论是，酮替芬与地西泮和5-羟色胺3受体拮抗剂一样，可减轻啮齿动物焦虑模型中的行为抑制，并减轻滥用药物撤药后的行为后果。
