肝脏和脑溶酶体及线粒体酶在0,0 - 二异丙基氟磷酸酯所致母鸡迟发性神经病发展过程中的作用
Role of liver and brain lysosomal and mitochondrial enzymes in development of delayed neuropathy in hens by 0,0-diisopropyl phosphorofluoridate.
作者信息
Dighe S K, Nashikkar A B, Dube D K, Batra B S, Chattopadhyay D P
出版信息
Indian J Exp Biol. 1989 Sep;27(9):809-12.
Subacute dose of 0,0-diisopropyl phosphorofluoridate (DFP), a potent organophosphorus ester capable of producing delayed neurotoxicity (OPIDN), did not produce any significant change in the levels of lysosomal and mitochondrial marker enzymes of brain, liver and serum at any time after treatment in hens protected with atropine. The results suggest the absence of any involvement of mitochondrial and lysosomal enzymes at any stage in the development of OPIDN in susceptible species by treating with DFP.
亚急性剂量的0,0-二异丙基氟磷酸酯（DFP）是一种能够产生迟发性神经毒性（OPIDN）的强效有机磷酸酯，在用阿托品保护的母鸡中，治疗后的任何时间，其脑、肝和血清中的溶酶体和线粒体标记酶水平均未发生任何显著变化。结果表明，在易感物种中，用DFP治疗后，OPIDN发展的任何阶段均不存在线粒体和溶酶体酶的参与。
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