School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
N Z Vet J. 2020 Jul;68(4):203-213. doi: 10.1080/00480169.2020.1729268. Epub 2020 Apr 19.
The fungal metabolite sporidesmin is responsible for the hepatogenous photosensitising disease facial eczema in livestock. Toxicity is due to a sulfur-bridged epidithiodioxopiperazine ring that has wide biological reactivity. The ways in which the toxin causes hepatobiliary and other tissue damage have not been established. Hypotheses include direct interaction with cellular thiols including protein cysteine residues or production of reactive oxygen species resulting in oxidative stress. Comparison with the cellular effects of the structurally related compound gliotoxin suggests additional mechanisms including interaction with cell adhesion complexes and possible downstream consequences for regulated necrosis as a response to tissue injury. Revision of hypotheses of how sporidesmin affects cells has the potential to generate new strategies for control of facial eczema including through identification of proteins and genes that are associated with resistance to the disease.
真菌代谢产物三亚豆素是引起家畜肝源性光敏病面部湿疹的原因。毒性是由于硫桥连接的表二硫二氧代哌嗪环具有广泛的生物反应性。毒素引起肝胆和其他组织损伤的方式尚未确定。假设包括与包括蛋白半胱氨酸残基在内的细胞硫醇的直接相互作用，或产生导致氧化应激的活性氧物质。与结构上相关的化合物Gliotoxin的细胞效应进行比较，表明存在其他机制，包括与细胞黏附复合物相互作用以及可能对组织损伤的作为对调节性细胞坏死的下游后果。修订关于三亚豆素如何影响细胞的假设，有可能为控制面部湿疹生成新的策略，包括通过鉴定与疾病抗性相关的蛋白质和基因。
