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2017年在大韩民国分离出的一种甲型猪流感变异株(H3N2)的完整编码序列

Complete Coding Sequence of a Swine Influenza A Variant (H3N2) Virus Isolated in the Republic of Korea in 2017.

作者信息

Noh Ji Yeong, Lo Van Thi, Kim Young Ji, Yoon Sun-Woo, Jeong Dae Gwin, Na Woonsung, Song Daesub, Kim Hye Kwon

机构信息

Department of Microbiology, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea.

Infectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

出版信息

Microbiol Resour Announc. 2020 Feb 13;9(7):e01355-19. doi: 10.1128/MRA.01355-19.

Abstract

Cases of human infection with a swine influenza A virus variant have been reported in the United States, and since 2011, H3N2 variant viruses have also been regularly isolated from swine in the Republic of Korea. Here, we genetically characterized an influenza A H3N2 isolate (A/swine/P17-4/2017). BLASTN analysis of the 8 gene sequences revealed a high degree of nucleotide similarity (97.0 to 99.0%) to porcine strains circulating in the Republic of Korea and the United States. Specifically, we found a high degree of similarity in the nucleotide matrix gene to those of recent isolates from North Carolina. Therefore, continuous epidemiological surveillance is necessary to monitor the variation and evolution of influenza A viruses.

摘要

美国已报告人类感染甲型猪流感病毒变异株的病例,自2011年以来,韩国也经常从猪身上分离出H3N2变异病毒。在此,我们对一株甲型H3N2流感病毒分离株(A/猪/P17 - 4/2017)进行了基因特征分析。对8个基因序列的BLASTN分析显示,其与在韩国和美国流行的猪毒株具有高度的核苷酸相似性(97.0%至99.0%)。具体而言,我们发现其核苷酸基质基因与来自北卡罗来纳州的近期分离株高度相似。因此,有必要持续进行流行病学监测,以监测甲型流感病毒的变异和进化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd0/7019062/87fa13e498bb/MRA.01355-19-f0001.jpg

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