Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.
Dutch Growth Research Foundation, Rotterdam, The Netherlands.
Eur J Clin Nutr. 2020 Apr;74(4):642-650. doi: 10.1038/s41430-020-0578-7. Epub 2020 Feb 13.
Accelerated gain in fat mass (FM) in early life increases the risk for adult diseases. Longitudinal data on infant body composition are crucial for clinical and research use, but very difficult to obtain due to limited measurement tools and unsuccessful measurements between age 6-24 months. We compared FM% by dual-energy X-ray absorptiometry (DXA), with cushion to reduce movement artifacts, with FM% by air-displacement plethysmography (ADP) and evaluated the reliability of this cushion during DXA by comparing FM% with and without cushion. Subsequently, we constructed sex-specific longitudinal body composition charts from 1-24 months.
In 692 healthy, term-born infants (Sophia Pluto Cohort), FM% was measured by ADP from 1-6 months and DXA with cushion from 6-24 months. At 6 months, FM% was measured in triplicate by ADP and DXA with and without cushion(n = 278), later on in smaller numbers.
At 6 months, mean FM% by DXA with cushion was 24.1 and by ADP 25.0, mean difference of 0.9% (Bland-Altman p = 0.321, no proportional bias). Mean FM% by DXA without cushion was 12.5% higher compared to ADP (Bland-Altman p < 0.001). DXA without cushion showed higher mean FM% compared to DXA with cushion (+11.6%, p < 0.001) at 6 months. Longitudinally, FM% increased between 1-6 months and decreased from 6-24 months(both p < 0.001).
In infants, DXA scan with cushion limits movement artifacts and shows reliable FM%, comparable to ADP. This allowed us to construct longitudinal body composition charts until 24 months. Our study shows that FM% increases from 1-6 months and gradually declines until 24 months.
婴儿早期脂肪量（FM）的快速增加会增加成年后患病的风险。婴儿身体成分的纵向数据对于临床和研究使用至关重要，但由于测量工具有限且在 6-24 个月之间的测量结果并不成功，因此很难获得。我们通过双能 X 射线吸收法（DXA）比较了使用垫子减少运动伪影后的 FM%，与空气置换体描记法（ADP）的 FM%，并通过比较有垫和无垫时的 FM%来评估该垫子在 DXA 期间的可靠性。随后，我们从 1 至 24 个月构建了性别特异性的纵向身体成分图表。
在 692 名健康、足月出生的婴儿（Sophia Pluto 队列）中，在 1-6 个月期间通过 ADP 测量 FM%，在 6-24 个月期间使用带有垫子的 DXA 测量 FM%。在 6 个月时，通过 ADP 和带有或不带有垫子的 DXA 重复测量了 3 次 FM%（n=278），之后的测量次数较少。
在 6 个月时，DXA 带垫的 FM%平均值为 24.1%，ADP 为 25.0%，平均差值为 0.9%（Bland-Altman p=0.321，无比例偏差）。DXA 无垫的 FM%平均值比 ADP 高 12.5%（Bland-Altman p<0.001）。与 DXA 带垫相比，DXA 无垫在 6 个月时显示出更高的平均 FM%（高 11.6%，p<0.001）。纵向分析显示，FM%在 1-6 个月之间增加，在 6-24 个月之间减少（均 p<0.001）。
在婴儿中，使用垫子的 DXA 扫描可限制运动伪影，并显示可靠的 FM%，与 ADP 相当。这使我们能够构建直到 24 个月的纵向身体成分图表。我们的研究表明，FM%从 1-6 个月增加，然后逐渐减少到 24 个月。
