Greene Heather R, Krasowski Matthew D
Carver College of Medicine, University of Iowa, IA, USA.
Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Data Brief. 2020 Jan 27;29:105189. doi: 10.1016/j.dib.2020.105189. eCollection 2020 Apr.
Ingestion of toxic alcohols other than ethanol (ethylene glycol, methanol, isopropanol, and propylene glycol) can cause life-threatening complications including altered level of consciousness, respiratory depression, and organ damage from metabolites. Many hospitals lack the ability to specifically analyze these compounds using gas chromatography, gas chromatography/mass spectrometry, or by enzymatic assays for ethylene glycol. Consequently, the presence of these compounds in blood is often ascertained indirectly by laboratory testing for acid-base status, osmolal gap, and anion gap. In the related research article, we analyzed 260 samples originating from 158 unique patients that had osmolal gap and specific testing for toxic alcohols performed on serum/plasma at an academic medical center central clinical laboratory. The data in this article provide the patient demographic, osmolal gap (and associated laboratory tests needed for this calculation), ethanol concentration by enzymatic assay, specific testing for toxic alcohols (ethylene glycol, isopropanol, methanol, propylene glycol) and acetone, anion gap, clinical history, antidotal treatment, and estimated timing of ingestion. The analyzed data is provided in the supplementary tables included in this article. Bias plots of osmolal gap estimations are included in a figure. The dataset reported is related to the research article entitled "Correlation of Osmolal Gap with Measured Concentrations of Acetone, Ethylene Glycol, Isopropanol, Methanol, and Propylene Glycol in Patients at an Academic Medical Center" [1].
摄入除乙醇之外的有毒醇类（乙二醇、甲醇、异丙醇和丙二醇）可导致危及生命的并发症，包括意识水平改变、呼吸抑制以及代谢产物造成的器官损害。许多医院缺乏使用气相色谱法、气相色谱/质谱联用技术或乙二醇酶法测定来专门分析这些化合物的能力。因此，血液中这些化合物的存在情况通常通过检测酸碱状态、渗透压间隙和阴离子间隙来间接确定。在相关研究文章中，我们分析了来自158名独特患者的260份样本，这些样本在一家学术医疗中心的中央临床实验室进行了渗透压间隙测定以及血清/血浆中有毒醇类的特异性检测。本文中的数据提供了患者人口统计学信息、渗透压间隙（以及计算所需的相关实验室检测结果）、酶法测定的乙醇浓度、有毒醇类（乙二醇、异丙醇、甲醇、丙二醇）和丙酮的特异性检测结果、阴离子间隙、临床病史、解毒治疗以及估计的摄入时间。分析数据列于本文附带的补充表格中。渗透压间隙估计值的偏差图包含在一幅图中。所报告的数据集与题为《学术医疗中心患者渗透压间隙与丙酮、乙二醇、异丙醇、甲醇和丙二醇测定浓度的相关性》的研究文章相关[1]。
