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初诊去势敏感性转移性前列腺癌的治疗模式变化。

The changing landscape in the management of newly diagnosed castration sensitive metastatic prostate cancer.

机构信息

Department of Urology, University of Oklahoma Health Sciences Center, Stephenson Cancer Center, Oklahoma City, OK, USA.

出版信息

Investig Clin Urol. 2020 Feb;61(Suppl 1):S3-S7. doi: 10.4111/icu.2020.61.S1.S3. Epub 2020 Jan 16.

DOI:10.4111/icu.2020.61.S1.S3
PMID:32055749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7004830/
Abstract

Metastatic prostate cancer is a heterogeneous disease entity. Men without prior androgen deprivation therapy exposure are termed metastatic castration sensitive prostate cancer (mCSPC). The goal of this article is to update the reader on the rapidly changing landscape of treatment for men with mCSPC. Along with the options available to the clinician for treatment of men with mCSPC, the care of these patients has evolved into a multi-disciplinary field with expanding roles for medical, urologic, and radiation oncologists.

摘要

转移性前列腺癌是一种异质性疾病实体。未经雄激素剥夺治疗(androgen deprivation therapy)暴露的男性被称为转移性去势敏感前列腺癌(metastatic castration sensitive prostate cancer,mCSPC)。本文的目的是使读者了解 mCSPC 男性治疗领域的快速变化。随着临床医生为 mCSPC 男性提供的治疗选择的增加,这些患者的护理已发展成为一个多学科领域,医学、泌尿科和放射肿瘤学家的角色不断扩大。

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本文引用的文献

1
ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer.ARCHES:雄激素剥夺治疗联合恩扎卢胺或安慰剂治疗转移性去势敏感性前列腺癌的随机 III 期研究。
J Clin Oncol. 2019 Nov 10;37(32):2974-2986. doi: 10.1200/JCO.19.00799. Epub 2019 Jul 22.
2
Management of Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): an Evolving Treatment Paradigm.转移性激素敏感型前列腺癌(mHSPC)的管理:一个不断发展的治疗范例。
Curr Treat Options Oncol. 2019 Jul 9;20(9):69. doi: 10.1007/s11864-019-0668-8.
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Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer.恩扎卢胺联合标准一线治疗转移性前列腺癌。
N Engl J Med. 2019 Jul 11;381(2):121-131. doi: 10.1056/NEJMoa1903835. Epub 2019 Jun 2.
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Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer.阿帕鲁胺治疗转移性去势敏感性前列腺癌。
N Engl J Med. 2019 Jul 4;381(1):13-24. doi: 10.1056/NEJMoa1903307. Epub 2019 May 31.
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Taxane-based chemohormonal therapy for metastatic hormone-sensitive prostate cancer: a Cochrane Review.基于紫杉烷的化学生物激素治疗转移性激素敏感前列腺癌:一项 Cochrane 综述。
BJU Int. 2019 Sep;124(3):370-372. doi: 10.1111/bju.14711. Epub 2019 Mar 20.
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Cancer statistics, 2019.癌症统计数据,2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
7
Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.新诊断转移性前列腺癌原发肿瘤放疗(STAMPEDE):一项随机对照 3 期试验。
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