Zardawi I M, Jarvis L, Hersey P, Francis L, Shaw H, Grace J
Discipline of Pathology, Faculty of Medicine, University of Newcastle.
Pathology. 1988 Jul;20(3):243-6. doi: 10.3109/00313028809059500.
DNA ploidy in benign nevi (BN), thin non-metastasizing melanomas (TNM) and thin metastasizing melanomas (TMM) was investigated using an image analyser to determine whether characteristics such as nuclear area (NA) and nuclear integrated optical density (IOD) could be used to distinguish between these lesions. NA measurements showed significant differences between samples of nevus cells and melanoma cells and nuclear IOD differences were significant between TNM and TMM samples. Differences in NA and nuclear IOD were detected across the three groups (BN, TNM and TMM) but the large variability within samples and within groups indicate further studies would be necessary to determine the usefulness of these results in terms of the rate of correct group classification of a single sample for diagnostic purposes.
使用图像分析仪研究良性痣（BN）、薄型非转移性黑色素瘤（TNM）和薄型转移性黑色素瘤（TMM）中的DNA倍性，以确定诸如核面积（NA）和核积分光密度（IOD）等特征是否可用于区分这些病变。NA测量显示痣细胞和黑色素瘤细胞样本之间存在显著差异，TNM和TMM样本之间的核IOD差异也很显著。在三组（BN、TNM和TMM）中均检测到NA和核IOD的差异，但样本内和组内的巨大变异性表明，有必要进一步研究以确定这些结果在单个样本正确分组诊断率方面的有用性。
