Department of Breast and Thoracic Oncological Surgery, The First Affiliated Hospital of Hainan Medical University, 31, Longhua RD, Haikou, 570102, Hainan, China.
Nanjing Medical University, Nanjing, 210000, Jiangsu, China.
Breast Cancer Res Treat. 2020 Apr;180(2):481-490. doi: 10.1007/s10549-020-05561-1. Epub 2020 Feb 13.
Breast cancer is a major public health concern worldwide and shows significant heterogeneity between male and female. Knowing the global incidence landscape in both sexes is critical for the breast cancer prevention and the reduction in disease burden.
We retrieved the incidence data of breast cancer in both sexes from the Global Burden of Disease 2017 database. Average annual percentage change was used to quantify the temporal trends of breast cancer incidence.
Between 1990 and 2017, the number of newly diagnosed female breast cancer (FBC) cases increased from 870.2 thousand to 1937.6 thousand, with the age-standardized incidence rate (ASR) significantly increased from 39.2/100,000 to 45.9/100,000. A total of 166 countries experienced a significant increase in FBC-ASR. The most pronounced increase was mainly found in developing countries. The decrease was mostly detected in several developed countries, such as the USA and the UK. Male breast cancer (MBC) is a rare carcinoma and has no evident cluster across the world. Worldwide, the number of newly diagnosed MBC cases increased from 8.5 thousand in 1990 to 23.1 thousand in 2017, with the ASR significantly increased from 0.46/100,000 to 0.61/100,000. A total of 123 countries showed a significant increasing trend in MBC-ASR.
Breast cancer incidence rates are increasing in most countries in both sexes, although the epidemiological features were not completely shared between FBC and MBC. More emphases should be placed on breast cancer primary prevention and the prevention strategies might need to be tailored for both FBC and MBC.
乳腺癌是全球重大公共卫生问题，在男性和女性之间存在显著异质性。了解两性乳腺癌的全球发病率情况对于乳腺癌的预防和降低疾病负担至关重要。
我们从 2017 年全球疾病负担数据库中检索了两性乳腺癌的发病率数据。使用年均变化百分比来量化乳腺癌发病率的时间趋势。
1990 年至 2017 年间，女性乳腺癌（FBC）新发病例数从 87.02 万例增加到 193.76 万例，年龄标准化发病率（ASR）从 39.2/10 万显著增加到 45.9/10 万。共有 166 个国家 FBC-ASR 显著上升。增幅最大的主要是发展中国家。发病率下降主要发生在一些发达国家，如美国和英国。男性乳腺癌（MBC）是一种罕见的癌种，在全球范围内没有明显的聚集现象。1990 年至 2017 年间，全球新诊断的 MBC 病例数从 8500 例增加到 23100 例，ASR 从 0.46/10 万显著增加到 0.61/10 万。共有 123 个国家的 MBC-ASR 呈显著上升趋势。
尽管 FBC 和 MBC 的流行病学特征不完全相同，但大多数国家男性和女性的乳腺癌发病率都在上升。应更加重视乳腺癌的一级预防，预防策略可能需要针对 FBC 和 MBC 进行调整。
