Lindner W, Schaumberger M, Versmold H T
Department of Pediatrics, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
Pediatr Res. 1988 Nov;24(5):613-6. doi: 10.1203/00006450-198811000-00015.
Ophthalmic artery blood flow velocity (OA-BFV, cm/s), cerebral blood flow velocity (C-BFV, cm/s), and cardiac output (ml/min) were measured by pulsed Doppler sonography in 15 healthy term and 10 well preterm (26-35 wk) infants in the first week of life. OA-BFV did not increase with increasing gestational age (preterm: peak systolic BFV 29 +/- 5 cm/s, mean BFV 7.2 +/- 1.5 cm/s; term: peak systolic BFV 27 +/- 5 cm/s, mean BFV 6.6 +/- 1.3 cm/s), unlike C-BFV (preterm: peak systolic BFV 34 +/- 8 cm/s, mean BFV 9.4 +/- 2.3 cm/s; term: peak systolic BFV 43 +/- 9 cm/s, p less than 0.05; mean BFV 11 +/- 3.0 cm/s, p less than 0.05) and cardiac output (preterm 329 +/- 128 ml/min, term 732 +/- 112 ml/min; p less than 0.001). The ratio of OA-BFV/C-BFV was significantly higher in preterm than in term infants (p less than 0.01). In preterm infants, but not in term infants, there was a positive linear correlation of OA-BFV to C-BFV (r = 0.88). We conclude that it is possible to measure opthalmic artery blood flow velocity in neonates by pulsed Doppler sonography. Gestational age has different effects on OA-BFV and on C-BFV. Although it is a point of discussion if blood flow velocities are reflecting absolute blood flow, Doppler assessment of OA-BFV could be a tool for monitoring risk factors for retinopathy of prematurity.
采用脉冲多普勒超声测量了15名足月健康婴儿和10名健康早产儿（26 - 35周）出生后第一周的眼动脉血流速度（OA - BFV，cm/s）、脑血流速度（C - BFV，cm/s）和心输出量（ml/min）。与C - BFV不同，OA - BFV并不随胎龄增加而升高（早产儿：收缩期峰值BFV为29±5 cm/s，平均BFV为7.2±1.5 cm/s；足月儿：收缩期峰值BFV为27±5 cm/s，平均BFV为6.6±1.3 cm/s），C - BFV（早产儿：收缩期峰值BFV为34±8 cm/s，平均BFV为9.4±2.3 cm/s；足月儿：收缩期峰值BFV为43±9 cm/s，p<0.05；平均BFV为11±3.0 cm/s，p<0.05）和心输出量（早产儿为329±128 ml/min，足月儿为732±112 ml/min；p<0.001）。早产儿的OA - BFV/C - BFV比值显著高于足月儿（p<0.01）。在早产儿中，而不是足月儿中，OA - BFV与C - BFV呈正线性相关（r = 0.88）。我们得出结论，通过脉冲多普勒超声测量新生儿眼动脉血流速度是可行的。胎龄对OA - BFV和C - BFV有不同影响。尽管血流速度是否反映绝对血流量尚有争议，但OA - BFV的多普勒评估可能是监测早产儿视网膜病变危险因素的一种工具。
