Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Invest Ophthalmol Vis Sci. 2010 Feb;51(2):708-11. doi: 10.1167/iovs.09-4206. Epub 2009 Sep 8.
To evaluate normal blood flow velocity and Doppler indices of the ophthalmic arteries from birth to hospital discharge of inborn infants at birth weights between 500 and 1500 g and gestational age <or=32 weeks.
A longitudinal prospective study with Doppler ultrasound was conducted in both eyes at 24 hours, 7 and 28 days, and hospital discharge for systolic and diastolic velocities, pulsatility, and resistance indices. Retinopathy of prematurity stage 2 and higher, peri-intraventricular hemorrhage grades 3 and 4, and death were excluded.
The authors studied 46 very-low-birth-weight infants (92 eyes; birth weight, 1215 +/- 202 g; gestational age, 30.4 +/- 1.3 weeks). Both eyes had similar Doppler findings at each study interval. Systolic velocity increased significantly from birth to hospital discharge (P = 0.001; right eye, 17.85 +/- 5.3 cm/s and 23.18 +/- 4.88 cm/s; left eye, 17.78 +/- 5.19 cm/s and 23.51 +/- 5.63 cm/s), as did diastolic velocity (P = 0.02; right eye, 6.17 +/- 1.13 cm/s and 6.76 +/- 1.12 cm/s; left eye, 6.34 +/- 1.26 cm/s and 6.9 +/- 1.53 cm/s). Pulsatility and resistance indices did not change during the entire period.
There is a typical pattern of ophthalmic artery systolic and diastolic blood flow velocities, and pulsatility and resistance indices during the neonatal period in very-low-birth-weight infants.
评估出生体重在 500 至 1500 克之间且胎龄<32 周的新生儿从出生到出院期间眼动脉的正常血流速度和多普勒指数。
对 46 名极低出生体重儿（92 只眼；出生体重 1215±202g；胎龄 30.4±1.3 周）进行了前瞻性纵向研究，分别在出生后 24 小时、7 天和 28 天以及出院时进行了双眼的收缩期和舒张期速度、搏动指数和阻力指数多普勒超声检查。排除了早产儿视网膜病变 2 期及以上、脑室内出血 3 级和 4 级和死亡的病例。
双眼在每个研究间隔均具有相似的多普勒发现。收缩期速度从出生到出院显著增加（P=0.001；右眼，17.85±5.3cm/s 和 23.18±4.88cm/s；左眼，17.78±5.19cm/s 和 23.51±5.63cm/s），舒张期速度也如此（P=0.02；右眼，6.17±1.13cm/s 和 6.76±1.12cm/s；左眼，6.34±1.26cm/s 和 6.9±1.53cm/s）。整个期间，搏动指数和阻力指数没有变化。
极低出生体重儿在新生儿期存在典型的眼动脉收缩期和舒张期血流速度以及搏动指数和阻力指数模式。
