4'-取代山柰酚的合成与生物评价。
Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols.
机构信息
Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
出版信息
J Org Chem. 2020 Mar 20;85(6):4279-4288. doi: 10.1021/acs.joc.9b03461. Epub 2020 Feb 27.
Abstract
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a -3 hydroxyl group and the second has a carboxymethoxy ether at the -3 position. Both series have variable substitution at the -4' position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.
摘要
描述了两个系列的五个山柰酚-3-醇的合成。第一组均具有-3 位羟基，第二组在-3 位具有羧甲氧基醚。两个系列在-4'位（即 OH、Cl、F、H、OMe）都有可变取代。山柰酚和羧甲氧基醚都被评估了抑制核糖体 S6 激酶（RSK）活性和癌细胞增殖的能力。
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