一种由[钯]钯生成俄歇电子发射体铑-103m的固体载体发生器。
A solid support generator of the Auger electron emitter rhodium-103m from [Pd]palladium.
作者信息
Jensen Andreas I, Zhuravlev Fedor, Severin Gregory, Magnus Charlotte Busk, Fonslet Jesper, Köster Ulli, Jensen Mikael
机构信息
Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark.
Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark.
出版信息
Appl Radiat Isot. 2020 Feb;156:108985. doi: 10.1016/j.apradiso.2019.108985. Epub 2019 Nov 14.
Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (Rh, T = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (Pd, T = 16.99 days). Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure Rh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
俄歇电子疗法是一种针对微小肿瘤的有吸引力的治疗方式。铑-103m（Rh，半衰期T = 56.1分钟）是一种有前景的俄歇电子发射体，可作为钯-103（Pd，半衰期T = 16.99天）的衰变产物获得。钯被螯合在16aneS4大环的亲脂性衍生物中，该络合物被捕获在C18柱上。用稀盐酸洗脱得到放射化学纯的铑。我们推测这是通过西拉德-查尔默斯效应和瞬时电离的结合实现的。
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