Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Sleep Research Center, National Yang-Ming University, Taipei, Taiwan.
Department of Pediatrics, Yang-Ming branch, Taipei City Hospital, Taipei, Taiwan.
J Affect Disord. 2020 Mar 1;264:130-137. doi: 10.1016/j.jad.2019.12.010. Epub 2019 Dec 7.
To examine the association between narcolepsy and anxiety disorders.
This population-based, retrospective case-control study analyzed Taiwan's National Health Insurance Research Database between 2000 and 2013. We included narcoleptic patients aged at least 12 years, diagnosed according to the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) code 347. The cases and the propensity score-matched controls were selected in a 1:4 ratio. Each subject with anxiety disorders (ICD-9-CM code 300) was required to visit the outpatient clinic at least three times within a year. Multivariate logistic regression and interaction analyses were used to calculate the association between anxiety disorders and narcolepsy.
This study enrolled 478 and 1912 subjects with and without narcolepsy, respectively. After adjusting for covariates, patients with anxiety disorders had an approximately 2.7 odds ratio of developing narcolepsy when compared to the control subjects (adjusted odds ratio [aOR)] = 2.7; 95% confidence interval [CI] = 1.699-4.344). Interaction analysis and subgroup analysis showed a higher incidence of previously diagnosed anxiety disorders in narcoleptic patients aged 12 to 17 years and female patients (aOR = 25.9; 95% CI = 15.194-42.896; aOR = 3.6; 95% CI = 1.818-7.062, respectively).
The narcolepsy and anxiety disorders were not distinguished by validated structural diagnostic instruments.
The results of this study revealed higher comorbidity rates of anxiety disorders in narcoleptic patients. The incidence of previously diagnosed anxiety disorders was higher in narcoleptic patients aged 12 to 17 years and female patients.
研究嗜睡症与焦虑障碍之间的关联。
本基于人群的回顾性病例对照研究分析了 2000 年至 2013 年期间台湾全民健康保险研究数据库。纳入年龄至少 12 岁的嗜睡症患者，根据国际疾病分类，第 9 版修订版（ICD-9-CM）代码 347 进行诊断。病例和倾向评分匹配的对照以 1:4 的比例选择。每位患有焦虑障碍（ICD-9-CM 代码 300）的患者均需要在一年内至少三次到门诊就诊。使用多变量逻辑回归和交互分析来计算焦虑障碍与嗜睡症之间的关联。
本研究共纳入 478 名和 1912 名患有和不患有嗜睡症的患者。在调整了混杂因素后，与对照组相比，患有焦虑障碍的患者发生嗜睡症的几率大约增加了 2.7 倍（调整后的优势比[aOR] = 2.7；95%置信区间[CI] = 1.699-4.344）。交互分析和亚组分析显示，12 至 17 岁和女性嗜睡症患者中，先前诊断为焦虑障碍的发生率更高（aOR = 25.9；95% CI = 15.194-42.896；aOR = 3.6；95% CI = 1.818-7.062）。
嗜睡症和焦虑障碍未通过有效的结构性诊断工具来区分。
本研究结果显示，嗜睡症患者焦虑障碍的共病率更高。在 12 至 17 岁和女性嗜睡症患者中，先前诊断为焦虑障碍的发生率更高。
