Department of Maternal, Child and Adolescent Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13Hangkong Road, Wuhan, China.
Department of Education, Culture and Sports, East Lake New Technology Development Zone, Wuhan, China.
J Affect Disord. 2020 Apr 1;266:143-150. doi: 10.1016/j.jad.2020.01.051. Epub 2020 Jan 13.
Previous gene-environment studies on depression have examined the interaction between FKBP5 gene and childhood trauma, but the results are inconsistent and few studies have focused on Asian adolescents. Psychological resilience may explain for the inconsistency. We examined the interaction between FKBP5 gene and childhood trauma on depressive symptoms in Chinese adolescents, and firstly explored the moderating role of resilience in the relationship.
This study comprised 942 participants (448 males, 47.6%) randomly recruited from four senior schools in Wuhan, Hubei of China. Depressive symptoms, childhood trauma, and resilience were respectively evaluated by the Center for Epidemiological Studies Depression Scale (CES-D), the Childhood Trauma Questionnaire (CTQ) and the Connor-Davidson Resilience Scale (CD-RISC). Three potentially functional FKBP5 polymorphisms were selected for genotyping.
Participants carrying minor alleles of FKBP5 polymorphisms (rs3800373, rs1360780, and rs4713916) and a haplotype derived from these variants displayed higher CES-D scores when exposed to childhood physical abuse after adjusting for demographic characteristics and resilience (all P < 0.01). The three-way interactions of FKBP5 SNPs, physical abuse, and resilience on depressive symptoms all yielded statistical significance after adjusting for demographic characteristics (β = -0.282 to -0.236; all P < 0.001).
Cross-sectional design, self- reported measurements and limited genotyped FKBP5 polymorphisms.
FKBP5 variants in combination with childhood physical abuse may increase more pronounced depressive symptoms among Chinese adolescents, while resilience plays a moderating role in the associations. Future research to examine the exact mechanism of resilience in these associations is needed.
以往关于抑郁症的基因-环境研究检验了 FKBP5 基因与儿童期创伤之间的相互作用，但结果不一致，且很少有研究关注亚洲青少年。心理弹性可能可以解释这种不一致性。我们检验了 FKBP5 基因与儿童期创伤在中国青少年抑郁症状之间的相互作用，并首次探索了韧性在其中的调节作用。
本研究纳入了 942 名参与者（448 名男性，47.6%），他们是从中国湖北武汉的四所高中随机招募的。抑郁症状、儿童期创伤和韧性分别通过流行病学研究中心抑郁量表（CES-D）、儿童期创伤问卷（CTQ）和 Connor-Davidson 韧性量表（CD-RISC）进行评估。选择了三个潜在的功能性 FKBP5 多态性进行基因分型。
在调整了人口统计学特征和韧性后，携带 FKBP5 多态性（rs3800373、rs1360780 和 rs4713916）的次要等位基因和由这些变体衍生的单倍型的参与者，在经历儿童期身体虐待后，CES-D 评分更高（均 P<0.01）。在调整了人口统计学特征后，FKBP5 SNP、身体虐待和韧性对抑郁症状的三向交互作用均具有统计学意义（β=-0.282 至-0.236；均 P<0.001）。
横断面设计、自我报告的测量和有限的 FKBP5 多态性基因分型。
FKBP5 变体与儿童期身体虐待相结合可能会增加中国青少年更明显的抑郁症状，而韧性在这些关联中起着调节作用。需要进一步研究以检验这些关联中韧性的确切机制。
